凋亡抑制蛋白Survivin和Bcl-2在子宫内膜异位症中的表达及相关性研究  

Inhibitor of apoptosis protein Survivin and Bcl-2 in endometriosis expression and their correlation

作　　者：李书艳[1] 

机构地区：[1]浙江省舟山市中医骨伤联合医院妇科,浙江舟山316000

出　　处：《中国现代医生》2012年第14期55-56,59,共3页China Modern Doctor

摘　　要：目的了解凋亡抑制蛋白Survivin和Bcl-2在子宫内膜异位症(EMs)中的表达及相关性。方法应用SP免疫组化方法检测在位内膜、异位内膜、及正常子宫内膜分别在增生期、分泌期凋亡抑制蛋白Survivin和Bcl-2的阳性率。结果凋亡抑制蛋白Survivin、Bcl-2分别在正常子宫内膜中无论是增生期还是分泌期均未见阳性表达,但凋亡抑制蛋白Survivin、Bcl-2在在位子宫内膜、异位子宫内膜中无论是增生期还是分泌期均存在阳性表达,且凋亡抑制蛋白Survivin、Bcl-2在异位子宫内膜中无论是增生期还是分泌期的阳性率均分别高于在位内膜的阳性率,差异具有统计学意义(P<0.05))。但Survivin、Bcl-2分别在异位内膜的增生期与分泌期阳性率比较,差异无统计学意义(P>0.05)。子宫内膜异位症组织中survivin蛋白表达与Bcl-2表达呈正相关(r=0.785,P=0.000)。结论Survivin、Bcl-2二者在异位内膜中共同协作抑制了异位内膜的凋亡,从而参与了子宫内膜异位症的发病过程。Objective To understand the inhibitor of apoptosis protein Survivin and Bcl-2 in endometriosis （EMs） in the expression and relevance. Methods By SP immunohistochemical method to detect eutopic endometrium, ectopic endometri- urn, and normal endometrium at proliferative phase, secretory phase inhibitor of apoptosis protein Survivin and Bcl-2 posi- tive rate. Results The inhibitor of apoptosis protein Survivin, bcl-2, respectively, both in the normal endometrium is prolif- erative or secretory phase showed no expression, but the inhibitor of apoptosis protein Survivin, Bel-2 in eutopic en- dometrium, ectopic endometrium in both proliferative or secretory phase exist in expression, and inhibitor of apoptosis pro- tein Survivin, Bel-2 in ectopic endometrium in both proliferative or secretory phase of the positive rates were higher than the reign of membrane-positive rate, there was statistically significant difference （P 〈 0.05）. However, Survivin, bcl-2 in ectopic endometrium were proliferative and secretory phase of the positive rate, the difference was not statistically signifi- cant （P 〉 0.05）. Endometriosis of survivin protein expression and Bcl-2 expression was positively correlated, the correlation coefficient （r = 0.785, P = 0.000）. Conclusion Survivin, Bel-2 in ectopic endometrium in the two work together to inhibit ectopic endometrial apoptosis, and thus involved in endometriosis pathogenesis.

关 键 词：凋亡抑制蛋白 SURVIVIN BCL-2 子宫内膜异位症 

分 类 号：R641[医药卫生—外科学]