电项针干预对老年性痴呆大鼠5-HT及CHATmRNA的影响  被引量:5

Effect of Electro-nape-acupunture Intervention on the 5-HT and CHATmRNA in Laboratory Rats with Senile Dementia

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作  者:霍金[1] 韩数[1] 

机构地区:[1]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150001

出  处:《针灸临床杂志》2012年第4期68-70,共3页Journal of Clinical Acupuncture and Moxibustion

摘  要:目的:研究电项针干预对老年性痴呆(AD)大鼠海马区五羟色胺(5-hydroxytryptamine,5-HT)及乙酰胆碱转移酶mRNA(CHATmRNA)的影响。方法:采用胃饲AlCl3水溶液,腹腔注射D-半乳糖制备AD大鼠模型,40只大鼠随机分为4组,应用免疫组化法和原位杂交法分别对各组大鼠5-HT及CHATmRNA的表达进行检测。结果:电项针治疗4周后5-HT和CHATmRNA阳性表达增强(P<0.05)。结论:电项针可以通过提高大鼠海马组织中5-HT和CHATmRNA的活性,达到抗老年性痴呆的作用。Objective:To study the effect of acupuncture intervention on senile dementia(Alzheimer ' s disease,AD) in the hippocampus of rats with five hydroxytryptamine(5-hydroxytryptamine,5-HT) and acetylcholine transferase mRNA(CHATmRNA).Methods:Use a gastric feeding AlCl3 aqueous solution,intraperitoneal injection of D-galactose to prepare model of AD rats,40 rats were randomly divided into four groups,using immunohistochemistry and in situ hybridization method separately for each group of rats to detect 5-HT and CHATmRNA expression.Results:Acupuncture treatment lasted four weeks,and 5-HT and CHATmRNA expression enhanced(P<0.05).Conclusion:Acupuncture can improve the rats' hippocampus 5-HT and CHATmRNA activity,which plays a positive role in anti-senile dementia.

关 键 词:电项针 老年性痴呆 五羟色胺 乙酰胆碱转移酶mRNA 

分 类 号:R245.97[医药卫生—针灸推拿学]

 

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