扎鲁司特对低氧性肺动脉高压大鼠的影响  

A study of influence of zafirlukast to anoxic pulmonary hypertension in rats

作　　者：庞宝森[1] 王辰[1] 周建群[1] 牛淑杰[1] 张洪玉[1] 翁心植[1] 黄秀霞[1] 张海燕[1] 

机构地区：[1]首都医科大学附属北京红十字朝阳医院呼吸病研究所,100020

出　　处：《中华结核和呼吸杂志》2000年第3期144-146,共3页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：北京市科技新星计划资助项目 !85 487110 0

摘　　要：目的　探讨扎鲁司特降低低氧性肺动脉高压的作用机制。方法　将Wistar大鼠 40只随机分为 4组 ,每组 10只 :(1)正常对照组 ;(2 )低氧性肺动脉高压模型组 ;(3)扎鲁司特预防组 ;(4)扎鲁司特治疗组。各组实验完毕 ,分别用心导管法测定平均肺动脉压 (mPAP) ,检测NO·2 /NO·3 、胶原、过氧化脂质 (LPO)、超氧化物歧化酶 (SOD)。结果　低氧组大鼠mPAP与正常对照组比较 ,差异有显著性 ,P <0 0 1。扎鲁司特预防、治疗组与正常对照组比较差异无显著性 ,P均 >0 0 5。预防组、治疗组与低氧组比较 ,P均 <0 0 1。低氧组大鼠血浆、支气管肺泡灌洗液、肺组织中一氧化氮 (NO)含量与正常对照组比较 ,P均 <0 0 1。预防组NO含量与低氧组比较差异有显著性 ,P <0 0 5 ,P <0 0 1。治疗组分别与低氧组比较差异有显著性 ,P均 <0 0 1。低氧组肺组织胶原含量与正常对照组比较差异有显著性 ,P <0 0 1;预防组、治疗组与低氧组比较差异有显著性 ,P <0 0 1,P <0 0 5。结论　扎鲁司特降低低氧性肺动脉高压的作用机制之一 ,与阻抑胶原蛋白在肺组织的沉积 ,调节NO含量 。Objective To investigate possible mechanism of the influence of zafirlukast to anoxic pulmonary hypertension in rats Methods Forty wistar rats were divided into four groups in random : (1) control group; (2) anoxic pulmonary hypertension group; (3) zafirlukast preventive group;(4) zafirlukast therapeutic group. Pulmonary arterial pressure was measured, naemo kinitic indexes were recorded Results In the anoxic group and control group, the difference of mPAP was remarkable, P <0 01 When zafirlukast preventive group and the therapeutic group compared with the control group, there was no statistical difference, P >0 05 When the preventive group and the therapeutic group compared with the hypoxia group, P <0 01 In the hypoxia group, the content of NO in the plasma, broncho alveolar lavage solution, and the lung tissue showed remarkable significance compared with that of control group, P <0 01 The content of NO ·2 /NO ·3 in the preventive group showed remarkable significance compared with hypoxia group, P <0 05, P <0 01 The content of NO ·2 /NO ·3 in the therapeutic group showed remarkable significance compared with hypoxia group, P <0 01 The content of collagen in hypoxia group was remarkable highened compared with that of control group, P <0 01 The content of collagen in preventive group and therapeutic group showed remarkable significance compared with hypoxia group, P <0 01, P <0 05 Conclusions The results indicate that zafirlukast can lower anoxic pulmonary hypertension, one of its mechanisms may be related with its depressing the sediment of collagen on lung tissue, adjusting NO level in rats and anti damaging effect of free radicals

关 键 词：扎鲁司特 低氧症 肺动脉高压 药物疗法 

分 类 号：R96[医药卫生—药理学]