弦式加载法延长面神经模型的建立  

ESTABL ISHMENT OF FACIAL NERVE EL ONGATION MODEL BY STRING- TYPE L OADING

作　　者：牙祖蒙[1] 陈宗基[2] 王建华[3] 李忠禹[3] 谭颍徽[3] 

机构地区：[1]中国医学科学院中国协和医科大学整形外科医院,北京100041 [2]中国医学科学院 [3]第三军医大学第二附属医院口腔科,重庆400037

出　　处：《中国修复重建外科杂志》2000年第2期90-92,共3页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：全军"九五"青年科研基金

摘　　要：目的　为使神经延长术更简便地应用于临床 ,尤其是用于面神经缺损的修复 ;同时更科学地研究周围神经的生物力学特性。方法　自行研制一种新的神经延长器 ,以弦式加载方式对面神经进行快速和缓慢延长 ,观察延长前后面神经的电生理及病理形态学变化。结果　延长器放置部位的组织无变性坏死 ,伤口及创面无感染 ,动物进食功能无障碍 ,体温不升高 ;病理学观察可见快速组神经出现散在的 Sunderland 度损伤 ,偶见毛细血管断裂 ,而缓慢组神经变粗 ,神经束间、外膜成纤维细胞增生 ;颊肌肌电图及神经传导速度检测显示 ,神经可延长极限快速组为 (18.7± 2 .4) % ,缓慢组为 (30 .8± 2 .4) % (均已除去回缩率 )。结论　所建立的神经延长模式和方法具有科学性和实用性 ,可用于神经延长的基础和临床研究。Objective To study the repairing method of facial nerve defect using nerve elongation,and the biomechanical properties of peripheral nerves. Methods A novel device for peripheral nerve elongation was designed and manufactured. With the device,facial nerves of rabbits were expanded acutely and chronically by string- type loading. The facial nerves were studied with histological and electrophysiological examinations before and after elongation. Results There were no considerable necrosis,degeneration,and infection in the facial nerves after elongation. The experimental anim als took food norm ally and their body temperature were stable. Histological exam inations showed dispersing Sunderland degree injury and occasionally broken capillary blood vessels in the acute group,thicker nerve and fibroblasts hyperplasia between nerve bundles in the chronic group. The electrom yogram (EMG) of buccal m uscle and nerve conductive velocity(NCV) showed the m aximal range was (18.7± 2 .4) % in the acute group,and (30 .8± 2 .4) % in the chronic group. Conclusion It suggests thatthe nov- el nerve elongation method is feasible ,and it can be used to study the nerve elongation basically and clinically.

关 键 词：面神经延长 弦式加载 面神经损伤 修复 

分 类 号：R651.3[医药卫生—外科学]