头孢美唑致迟发性严重静脉炎  

Severe delayed phlebitis caused by cefmetazole

作　　者：高凤[1] 

机构地区：[1]北京市平谷区医院药剂科,101200

出　　处：《药物不良反应杂志》2012年第2期129-130,共2页Adverse Drug Reactions Journal

摘　　要：1例49岁女性患者因急性上呼吸道感染给予头孢美唑2.0 g加入0.9%氯化钠注射液250 ml静脉滴注,2次/d,连用3 d后症状缓解停药。15 d后,患者左前臂出现肿胀疼痛,穿刺部位至肘关节处静脉血管明显凸出皮肤并呈条索状,硬度增加,压痛,沿着血管走向散在大小不等的红斑。诊断为迟发性静脉炎。给予外敷硫酸镁溶液和地塞米松磷酸钠注射剂及草木犀流浸液片。4周后症状逐渐好转,血管颜色由红色变为棕褐色。12周后血管颜色恢复至正常,血管硬度略有下降但弹性仍较差。A 49-year-old woman with acute upper respiratory tract infection received an IV infusion of cefmetazole 2.0 g in 250 ml of 0.9% sodium chloride solution twice daily. After 3 days of treatment, her symptoms improved and cefmetazole was stopped. Fifteen days later, pain and swelling occurred in her left forearm. Blood vessels from the puncture site to the elbow showed a obvious bulge in the skin and cord-like change, an increase in hardness of the vein, venous tenderness, scattered and variable size of erythema along the vein. She was diagnosed with de｜ayed phlebitis. Topical magnesium sulfate solution, dcxamethasone for injection, and melilotus extract tablets were given. After 4 weeks, her symptoms subsided gradually, the color of vessels changed from red to brown. After 12 weeks, the color of the vessels normalized. There was a slight decrease in hardness of the vein and blood vessels were less elastic.

关 键 词：头孢美唑 静脉炎 

分 类 号：R472[医药卫生—护理学]