不同程度慢性阻塞性肺疾病患者血浆抗凝血酶-Ⅲ水平的变化  

Change of Plasma Antithrombin Ⅲ Level in Patients with Chronic Obstructive Pulmonary Disease of Different Degree

作　　者：彭德珍[1] 

机构地区：[1]桂林医学院附属医院检验科,广西桂林541001

出　　处：《现代检验医学杂志》2012年第2期63-65,共3页Journal of Modern Laboratory Medicine

基　　金：广西壮族自治区卫生厅计划课题（编号：Z2011179）

摘　　要：目的检测不同程度慢性阻塞性肺疾病（COPD）患者血浆抗凝血酶-Ⅲ（AT-Ⅲ）水平并探讨其临床意义。方法根据肺功能将COPD组患者分为轻（25例，FEV1％Pre〉／-80％）、中（32例，50％≤FEVl％Pre（80％）、重（28例，30％≤FEV1％Pre〈50％）、极重（25例，FEV1％Pre^30％）四级，分别测定各级COPD患者血浆AT_Ⅲ表达水平并与健康对照组比较，分析AT-Ⅲ与第一秒用力肺活量占预计值的百分比（FEVl％Pre）的相关性。结果COPD患者血浆AT-Ⅲ活性（74．98士14．75）明显低于对照组（89．52士】4．06），t=4．485，各级COPD组之间血浆AT-Ⅲ活性差异有统计学意义（P〈0．01）。血浆AT-Ⅲ活性与FEVl％Pre呈正相关（r==0．435，P〈O．01）。结论COPD患者存在血液高凝状态，血浆AT．Ⅲ活性随COPD疾病严重程度进展而下降。所以监测AT-Ⅲ活性对防治COPD高凝状态的发生、发展有重要意义．Objective To study significance of serum antithrombin Ⅲ （AT-Ⅲ） in patients with chronic obstructive pulmonary disease and detect the change of AT-Ⅲ level in COPD patients of different degree. Methods COPD patients were divided in- to four groups：slight （25,FEV1%Pre≥80%）,moderate （32,50%FEVl%Pre〈80%）,serious （28,30%FEVl%Pre〈50%） and much serious （25, FEV1% Pre〈30%） groups strictly according to diagnosis standard. COPD patients were measured plasma levels of AT- Ⅲ expression and comparative analysis with the healthy control group AT- Ⅲ correlation with FEVIPre. Results The AT-Ⅲ level in patients with COPD was decreased significantly than that health control group. A- mong the patients groups, there also had distinctive difference （P〈0. 01）. Plasma AT-Ⅲ and FEV1% were positively corre- lated（r=0. 435, P〈C0. 01）. Conclusion A hypercoaguiability state existed in COPD patients. Moreover, the serum AT-Ill level showed a decreasing trend with the development of COPD stage So dynamic observation of AT-Ⅲ levels may have im- portant significance in estimation of the cases,prognosis and treatment in COPD patients.

关 键 词：慢性阻塞性肺疾病 抗凝血酶-Ⅲ 第一秒用力肺活量占预计值的百分比 

分 类 号：R563[医药卫生—呼吸系统]