2009-2010年广西临床肿瘤标志物检验室间质量评价结果分析  

Analysis of External Quality Assessment Result of Clinical Tumor Markers from 2009 to 2010 Year in Guangxi

作　　者：刘晓春[1] 黄钧[1] 何毅[1] 唐娟[1] 张金立[1] 周向阳[1] 

机构地区：[1]广西壮族自治区人民医院广西壮族自治区临床检验中心,南宁530021

出　　处：《现代检验医学杂志》2012年第2期143-147,共5页Journal of Modern Laboratory Medicine

摘　　要：目的通过开展肿瘤标志物检验室问质量评价，提高广西临床肿瘤标志物检验质量，实现实验室问检验结果可比。方法分析2009-2010年肿瘤标志物检验室间质量评价结果，比较不同方法学、不同检测系统组结果的差异。结果①各方法学组的CV值从小到大依次为电化学发光＜微粒子酶免疫分析＜化学发光＜时间分辨荧光免疫分析＜放射免疫分析；②进口检测系统组内变异系数（CV）较满意，CV值在3．71％～13．05％；国产检测系统组内CV值不够满意，CV值在16．92％～54．38％；③各批号不同检测系统靶值差距很大，不同栓测系统问结果可比性差；④项目年度合格率较低，2009年、2010年度各项目合格率分别为52．63％～69．05％和30．43％～61．02％。结论我区临床肿瘤标志物检验总体质量不高．实验室应选择符合临床需要的仪器设备，使用优质的试剂和室内质控品，做好室内质量控制工作，提高肿瘤标志物检验质量，实现实验室间检验结果的可比。Objective To implement the external quality assessment for tumor markers and improve the quality of clinical tumor marker tests in Guangxi, to achieve inter-laboratory test results of comparable. Methods Analysed the results of tumor markers in 2009-2010 year external quality assessment,comparing the results of different methods and different de- tection systems group. Results The coefficient of variation of different methods from small to large were electrochemilumi- nescence〈micropartical enzyme immunoassay〈chemiluminescence〈time-resolved fluorescence immunoassay〈radioimmu- noassay. The import detection systems groups’CV were acceptable, the CV range from 3.71 ~ to 13.05%. The domestic de- tection systems groups＇ CV were dissatified and the CV range from 16.92% to 54.38%. The targets in different detection systems were greatly variation and the compar ability of results between different detection systems were dissatisfac- tion. Test item had lower pass rates,the test item pass rates were range from 52. 63% to 69. 05%in 2009 year and range from 30. 43% to 61.02% in 2010 year. Conclusion The detection quality of tumor markers were dissatified in Guangxi. La- boratory should choose the required equipment,select high quality reagents and internal quality control materials,carry out a good internal quality control, improve the quality of tumor marker test, achieve the target for comparable to inter-laboratory test results.

关 键 词：肿瘤标志物 室间质量评价 

分 类 号：R446[医药卫生—诊断学]