围生儿出生缺陷相关因素调查分析  

Factors associated with the risk of perinatal birth defects

作　　者：裴凌云[1] 马瑞兰[2] 李福轮[1] 杜蔚云[2] 李芝兰[1] 

机构地区：[1]兰州大学公共卫生学院,甘肃730000 [2]甘肃省人口和计划生育委员会

出　　处：《中国生育健康杂志》2012年第3期182-184,共3页Chinese Journal of Reproductive Health

基　　金：甘肃省人口和计划生育委员会《甘肃省出生缺陷干预工程实施效果评价》项目专项经费资助

摘　　要：目的 探讨母亲孕期暴露因素与围生儿出生缺陷发生间的关系,为进一步指导优生优育和有效预防出生缺陷的发生提供科学依据.方法 采用1∶1 配对病例对照研究,分析176例先天缺陷儿母亲孕期暴露因素,采用单因素与多因素logistic回归分析出生缺陷可能发生的危险因素.结果 母亲患遗传病（OR=4.41,95 %CI=0.92～21.01）、孕期患流行性感冒（OR=1.99,95 %CI=0.99～3.98）、孕期服用保胎药（OR=2.47,95 %CI=0.98～6.15）是围生儿出生缺陷发生的危险因素;出生缺陷居前3位的依次为先天性心脏病、色素痣和脑积水.结论 母亲患遗传病,孕期患流行性感冒可能是出生缺陷发生的高危因素.Objective To investigate factors during pregnancy potentially associated with the risk of perinatal birth defects. Methods A 1 ： 1 case-control study was carried out to evaluate of factors in pregnancy among 176 cases with birth defects and healthy controls. The univariate and multiple logistic regression was used to analyze potential risk factors. Results Risk factors included genetic disease in mother （ OR =4.41,95 % CI： 0. 92-21.01 ）, influenza during pregnancy （OR = 1.99, 95 %CI： 0. 99-3.98）, and hazardous or toxic agents exposure during pregnancy （OR =2. 47, 95 % CI： 0. 98-6. 15）. The top 3 types included congenital heart disease, nevus and hydrocephalus. Conclusion Genetic disease in mothers and influenza during pregnancy may be associated with increased risk of perinatal birth defects.

关 键 词：出生缺陷 围生儿 孕期 病例对照 

分 类 号：R714.53[医药卫生—妇产科学]