粉防已甲素、乙素对L7712和S180细胞DNA、RNA和蛋白质合成的抑制作用  

INHIBITION OF TETRANDRINE AND DEMETHYL TETRANDRINE ON DNA, RNA AND PROTEIN SYNTHESES OF LEUKEMIA 7712 AND SARCOMA 180 CELLS

作　　者：刘力生[1] 郑荣梁[1] 葛祥斌 顾继杰[1] 张龙弟[1] 巨勇[2] 贾忠建[2] 

机构地区：[1]兰州大学生物系,兰州730000 [2]兰州大学天然有机研究室,兰州730000

出　　处：《中国药理学通报》1990年第1期53-55,共3页Chinese Pharmacological Bulletin

基　　金：中国科学院科学基金

摘　　要：粉防已甲素和乙素对L7712和S180癌细胞DNA合成的ID_(50)分别为2.6,3.5和27.5,24.5mg/L;它们对L7712细胞DNA合成的抑制是由DNA复制模板受到损伤而引起的。它们对两种癌细胞DNA和RNA的合成有很强的抑制作用,对蛋白质合成的抑制作用较弱。两种药物对癌细胞抑制程度和作用方式相似。The 50% inhibition doses ( ID50 ) of tetrandrine and demethyl tetrandrine on DNA synthesis in L7712 and Sl80 cells are 2.6, 3 .5mg/ L and 27.5, 24.5mg/L respectively. The DNA synthesis inhibition is likely due to DNA template damage caused by both natural products. The inhibition of DNA, RNA and protein syntheses by tetrandrine or demethyl tetrandrine increased with incubating time. The inhibiting activities of two natural products on DNA and RNA synthesis are s-tronger than on protein. There are no differences either in inhibiting activity or in inhibiting mechanism between two natural products.

关 键 词：粉防已甲素 粉防已乙素 癌细胞 

分 类 号：R965[医药卫生—药理学]