荞麦花粉水溶性黄酮部分、异紫堇定对沙土鼠脑缺血重灌流损伤的影响  

EFFECT OF POLLEN ELEMENT FROM BUCKWHEAT, AND ISOCORYDINE ON THE GERBILS SUBJECTED TO CEREBRAL ISCHEMIA AND THEN REPERFUSION

作　　者：李麟仙[1] 张玉敏[1] 王子灿[1] 魏均娴[2] 

机构地区：[1]昆明医学院病理生理教研室,650031 [2]昆明医学院植化研究室,650031

出　　处：《中国药理学通报》1990年第1期43-45,共3页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金

摘　　要：结扎沙土鼠双侧颈总动脉,继之重灌流。结果表明,荞麦花粉对45min脑缺血后重灌流6h的卒中指数及24h的死亡率均有明显抑制作用。其机制可能与抗氧化作用有关。异紫堇定对脑缺血重灌流损伤无保护作用。After 45 min ligation of the gerbils' bilateral carotid arteries and then 24h reperfusion,the effects of water soluble Pollen flavone element from buckwheat, Isocorydine on the stroke index of 45 min cerebral ischemia followed by reperfusion 6h and the mortality of reperfusion 24h were evaluated .The results indicated that pollen element from buckwheat could decrease the stroke index and mortality rate dramatically, while Isocorydine had no effects. It was speculated that the beneficial effects of pollen element from buckwheat on cerebral damage following ischemia with reperfusion might be due to its depressing effect on the metabolism of free radicals.

关 键 词：荞麦花粉 异紫堇定 脑缺血 药理 

分 类 号：R282.710.5[医药卫生—中药学]