血尿酸水平与冠心病的关联研究  

Association between Serum Uric Acid Level and Coronary Artery Disease

作　　者：唐艳芳[1] 刘智勇[1] 刘景艳[1] 何昕[1] 袁旭明[1] 谌承志[1] 彭一鸣[1] 徐艳霞[1] 刘伟[1] 钟如意[1] 王磊[1] 

机构地区：[1]湖南省浏阳市人民医院心血管内科,410300

出　　处：《中华全科医学》2012年第6期868-870,共3页Chinese Journal of General Practice

摘　　要：目的探讨血尿酸水平与冠心病及冠状动脉狭窄程度之间的关联。方法根据冠状动脉造影检查结果将所有研究对象分为病例组(306例)和对照组(321例),收集临床资料并测定血清尿酸及其他生物化学指标,结合造影情况,探讨血尿酸水平与冠心病及冠脉狭窄程度之间的相关性。结果病例组血尿酸水平(359.36±70.98)μmol/L显著高于对照组的(311.41±73.65)μmol/L,两组比较差异有统计学意义(P<0.01)。随着冠脉病变支数的增加,血尿酸水平也逐渐升高,差异具有统计学意义(F=6.618,P=0.001)。多因素Logistic回归分析显示,血尿酸升高是冠心病发生的独立危险因素(OR=1.249,95%CI:1.241～1.756;P=0.001)。结论本研究人群冠心病患者血尿酸水平显著升高,且与冠心病发生及冠脉狭窄程度相关,血尿酸水平升高可能是冠心病的一个独立危险因素。Objective To investigate the relationship between serum uric acid level and the coronary artery disease（CAD） and degree of coronary artery stenosis.Methods There were two groups of subjects were studied according to coronary arteriography and the clinical presentation,CAD group（n=306） and control group（n=321）.The clinical materials were collected and the serum uric acid level was tested.The association between the serum uric acid level and severity of coronary atherosclerosis was analyzed combined with the imaging of coronary arteriography.Results The serum uric acid level of the CAD group was（359.36±70.98）μmol/L,obviously higher than（311.41±73.65）μmol/L of the control group（P0.01）.And serum uric acid level was significantly associated with the severity of CAD（F=6.618,P=0.001）.After adjusting for confounding factors using multivariate regression analysis,serum uric acid also was an independent risk factor for CAD（OR=1.249,95% CI：1.241-1.756;P=0.001）.Conclusion The serum uric acid level was high in patients with CAD;it＇s an independent risk factor for CAD and may be useful as a predictor of the severity of coronary atherosclerosis.

关 键 词：血尿酸 冠心病 危险因素 相关性 

分 类 号：R541.4[医药卫生—心血管疾病]