N—甲基小檗胺扩血管作用原理的研究  

THE MECHANISM OF DILATING VASCULAR SMOOTH MUSCLE BY N-METHYLBERBAMINE

作　　者：罗大力[1] 高云瑞[1] 李文汉[1] 

机构地区：[1]哈尔滨医科大学药理学教研室,哈尔滨150086

出　　处：《中国药理学通报》1990年第1期30-33,共4页Chinese Pharmacological Bulletin

摘　　要：N—甲基小檗胺可非竞争性抑制氯化钾、氯化钙、去甲肾上腺素引起的家兔胸主动脉条收缩。其拮抗参数pD_(2’)分别为3.44、3.67和3.73。对去甲肾上腺素引起的外钙性收缩有抑制作用,对内钙性收缩无影响,说明其作用原理与拮抗钙离子内流有关。The study showed that NMBA could inhibit the rabbit thoracic aorta contractions induced by KC1, CaCl2 and NA, and the pD' 2 values were 3.44, 3.67 and 3.73 respectively. NMBA could also antagonize the extracellular Ca2 + contraction of NA with no effect on the intra-cellular Ca2+ contraction. Comparing with verapamil, the mechanism of NMBA action was inferred to blocking Ca2+ influx during excitation. However, further study will be needed.

关 键 词：N-甲基小檗胺 扩血管作用 

分 类 号：R965[医药卫生—药理学]