18β—甘草次酸钠对炎症和免疫功能的影响  

EFFECTS OF 18β-SODIUM GLYCYRREHETIC ACID (SGA)ON INFLAMMATION AND IMMUNE FUNCTION

作　　者：李新芳[1] 孟富敏[1] 潘福生[1] 林卫[1] 兰中芬[2] 王风莲[2] 骆勤[2] 王越[2] 

机构地区：[1]兰州医学院药理教研室,730000 [2]兰州医学院微生物学教研室,730000

出　　处：《中国药理学通报》1990年第2期105-108,共4页Chinese Pharmacological Bulletin

摘　　要：甘草次酸钠是中药甘草主要成分甘草次酸的盐类。对多种动物的急慢性炎症模型均有明显的抑制作用,其作用强度与氢化可的松相近似。SGA对机体非特异性细胞免疫功能也有增强作用。本品毒性较小。The pharmacological effects of SGA on dogs, mice and rats were studied. The experimental results showed that SGA significantly inhibited capillary permeably induced by phlogistic stimulants and exudation induced by croton oil. Both the edema of the hind paw in the rats by means of egg-white and the granuloma formation in the rats' shoulders by round paper were inhibited. It's of an equal antiinflam-matory effect as hydrocortisone. Intraperitoneal injection of SGA increased in the ability of macrophage phagocytosis on cock RBC in rats' abdominal cavities. Eleven dogs were given IV 10 or 100 mg/kg daily for 15d. The major target organs of heart, liver, kidney and gastric intestine tract were found no toxicity.

关 键 词：甘草次酸钠 抗炎作用 免疫增强 

分 类 号：R282.710.5[医药卫生—中药学]