小檗胺对大鼠脑皮层梗塞的保护作用  

THE PROTECTIVE EFFECT OF BERBAMINE ON CEREBRAL INFARCTION MODEL IN RATS

作　　者：包力华[1] 李风林[1] 李文汉[1] 

机构地区：[1]哈尔滨医科大学药理教研室,黑龙江150086

出　　处：《中国药理学通报》1990年第2期102-104,共3页Chinese Pharmacological Bulletin

摘　　要：用伊文思蓝定量测定和TTC染色法,观察小檗胺对大鼠脑皮层梗塞的保护作用。结果表明:结扎大脑中动脉和同侧颈总动脉,再同时夹闭对侧颈总动脉1h,可引起大鼠脑皮层大脑中动脉分布区较大面积梗塞。小檗胺可使梗塞区伊文思蓝蓝染程度变浅,TTC染色梗塞范围缩小。说明该药对脑梗塞可能有保护作用。The cerebral infarction model was made according to Chen et al To evaluate the severity of infarction the quantity of Evan's blue was measured. The cerebral infarction size was determined by TTC stain. The results showed that ligating the right common carotid artery and the right middle cerebal artery and clamping the left common carotid artery could induce cerebral cortex in farction. Berbamine could decreased the level of Evan's blue and reduce the infarction size compared with control group. It suggests that berbamine possesses protective effect on experimental induced cerebral infarction.

关 键 词：小檗胺 脑栓塞 伊文思蓝 TTC 

分 类 号：R282.710.5[医药卫生—中药学]