双炔失碳酯经阴道给药的抗生育研究  

ANTIFERTILITY EFFECTS OF ANORDRIN ADMINISTERED VIA VAGINA IN RATS

作　　者：钱耀贤 沈佩娟[1] 徐瑞英[1] 刘桂明[1] 卢琦华[1] 李瑞麟[1] 

机构地区：[1]上海市计划生育科学研究所,200032

出　　处：《中国药理学通报》1990年第2期122-125,共4页Chinese Pharmacological Bulletin

摘　　要：双炔失碳酯为一种女用口服探亲避孕药。实验证明本品在动物经阴道给药具有显著的抗生育作用。其抗着床作用优于口服给药法。经阴道给药法方便易行,且无明显不良反应。本资料可为临床研究提供借鉴。Anordrin, which has been widely used as an oral contraceptive tablet in China, administered intra-vaginally at different levels of dose possessed marked antifertiiity effects in Sprague Dawley rats. The anti-implantation efficiency of the compound given intra-vaginally was superior to that of oral dosing in some respects. This kind of medication was feasible, convenient to use and with no serious side effects. Our investigation provides the experimental date for clinical study of using this drug vaginally.

关 键 词：双快失碳酯 抗生育 

分 类 号：R965.1[医药卫生—药理学]