罗格列酮对非糖尿病代谢综合征患者血清脂联素水平的影响  

The influence of rosiglitazone on serum adiponectin levels in metabolic syndrome patients without diabetes

作　　者：温慧华[1] 牛利军[2] 

机构地区：[1]包钢医院心内科,内蒙古包头014010 [2]包头市卫生局卫生监督所公共场所监督科,内蒙古包头014030

出　　处：《疾病监测与控制》2012年第5期268-270,共3页Journal of Diseases Monitor and Control

摘　　要：目的研究非糖尿病代谢综合征患者服用罗格列酮之后血清脂联素水平的变化,分析罗格列酮干预对血清脂联素的影响。方法选择非糖尿病代谢综合征患者92例,应用酶联免疫吸附法测定所有受试者血清脂联素水平,将入选患者随机分为两组,A组40例,给予低盐低脂饮食、常规降压及降血脂药物治疗;B组52例,在上述治疗的基础上,加用过氧化体增殖物激活受体-γ(PPAR-γ)激动剂罗格列酮(4mg/d)口服,8周后复查脂联素水平。结果 (1)A组治疗前后脂联素水平比较无统计学差异(1.49±0.59 mg/l,1.21±0.66 mg/l,P>0.05);(2)B组治疗前后比较,脂联素水平升高,有统计学差异(0.89±0.73mg/l,2.52±1.37 mg/l,P<0.01)。结论非糖尿病代谢综合征患者经口服PPAR-γ激动剂罗格列酮后脂联素水平明显升高,提示罗格列酮可提高非糖尿病代谢综合征患者脂联素水平。Objective To investigate the change of serum adiponectin levels in metabolic syndrome patients without diabetes after rosiglitazone （ROS） treatment and to analyse the influence of rosiglitazone on serum adiponectin levels. Methods 92 metabolic syndrome patients without diabetes were investigated. Serum adiponectin levels of all subjects were determined by using enzyme linked immunosorbent assay （ELISA）. All subjects were divided randomly into two groups ： A group 40 patients, B group 52 cases. On the basis of taking low-lipid and low-salt diet, the patients of two groups were administrated with reducing blood pressure and blood lipid positively. Furthermore, ROS （4mg/d）, which is the excitomotor of peroxidase prolifer-activited receptor-T （PPAR-T） was used for treatment by the patients of B group. After 8 weeks, serum adiponectin level was remeasured. Results （1） After reducing blood pressure and blood lipid positively, the serum adiponectin level have no significant change in A group, （1.49±0.59mg/l,1.21±0.66mg/l, P〉 0.05 ）. （2） There was a significant increasing in serum adiponectin levels （0.89± 0.73 m g/1, 2.52±1.37 m g/1, P〈 0.01 ）. Conclusions There was a significant increasing in serum adiponectin level after ROS treatment in metabolic syndrome cases without diabetes. This shows the level of serum adiponectin can be increased through ROS treatment.

关 键 词：代谢综合征 脂联素 罗格列酮 

分 类 号：R589[医药卫生—内分泌]