冠心病患者血清SAA、IL-6、TNF-α和hs-CRP检测及临床意义探讨  

Clinical significance of determination of the levels of serum SAA,IL-6,TNF-α and hs-CRP in patients with coronary heart disease(CHD)

作　　者：张珺[1] 李慧明[1] 叶素惠[1] 

机构地区：[1]深圳市龙岗中心医院保健科,518116

出　　处：《中国实用医药》2012年第10期1-3,共3页China Practical Medicine

摘　　要：目的检测冠心病(CHD)患者、血清淀粉样蛋白(SAA)及白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和超敏C-反应蛋白(hs-CRP)的变化,探讨其在CHD发病机制中的意义。方法检测22例急性心肌梗死(AMI)、25例不稳定性心绞痛(UA)、30例稳定性心绞痛(SA)、30例健康者血清SAA、IL-6、TNF-α和hs-CRP水平。结果 CHD患者血清SAA、IL-6、TNF-α和hs-CRP水平均较对照组高(P<0.01);并呈AMI>UA>SA的趋势(P<0.05和0.01),且在冠脉单支病变、双支病变、三支病变者逐渐增高(P<0.01);SAA与IL-6、TNF-α和hs-CRP水平显著相关(P<0.01)。结论 SAA、IL-6、TNF-α和hs-CRP可能参与了CHD的发病过程,可作为CHD病情观察的指标,以预防CHD急性冠脉事件的发生。Objective To detect the changes of serum amyloid A protein （SAA）, interleukin-6 （IL- 6 ）,tumor necrosis faetorct （TNF-a）and hypersensitive C-reactive protein （hs-CRP） in patients with coronary heart disease （CHD） , and investigate the significance in the pathogenesis of CHD. Methods We detected the levels of SAA, IL-6, TNF-a and hs-CRP in 22 patients with acute myocardial infarction （AMI） ,25patients with unstable angina （UA） , 30 patients with stable angina （SA） and 30 healthy volunteers. Results The levels of SAA, IL-6, TNF-a and hs-CRP were higher in patients with CHD than those in the healthy control group （P 〈 0. 01 ） ,and had a tendency of AMI 〉 UA 〉 SA（ P 〈 0. 05 and 0. 01 ）. A significant correlation were found between SAA and IL-6, TNF-a and hs-CRP（P 〈0. 01 ）. Conclusion The levels of SAA,IL-6,TNF-a,hs-CRP which may be involved in CHD development and act as observational indices of patients condition, can prevent the acute coronary events in patients with CHD.

关 键 词：冠状动脉疾病 血清淀粉样蛋白A 白介素-6 肿瘤坏死因子-α 超敏C-反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]