左旋四氢巴马汀对几种激动剂所致气管收缩作用的影响  

EFFECT OF L-THP ON CONTRACTION OF ISOLATION GUINEA PIG TRACHEA INDUCED BY SEVERAL AGONISTS

作　　者：吴绍光[1] 李晓兰[1] 赵国举[1] 

机构地区：[1]同济医科大学郧阳医学院药理教研室,十堰442000

出　　处：《中国药理学通报》1990年第3期179-182,共4页Chinese Pharmacological Bulletin

摘　　要：在离体豚鼠气管螺旋条L—THP抗BaCl_2,KCl,5-HT,His,Ach所致收缩作用与Ver及Pap均不同。L-THP抗BaCl_2,KCl,5-HT,His次最大反应量所致收缩的IC_(50)值分别为3.5×10^(-5)mol/L,4.5×10^(-5)mol/L,2.5×10^(-5)mol/L,8.9×10^(-5)mol/L。各激动剂对L—THP的敏感性与其对胞外钙的相对依赖性顺序相一致。但L-THP抗KCl及5-HT的作用强度无显著差异,提示L-THP能阻断钙内流并具相似强度的抗5-HT作用。The antagonistic effects of L-THP, Ver and Pap to contraction of isolated guinea pig trachea preparations induced by BaCl2 10-3mol/L ,KC1 3×10-2mol/L, 5-HT 2×10-5mol/L, Ach 2×10-5mol/L and His 2× 10-5mol/L were studied. The antagonistic effects of L-THP were different from Ver and Pap. The IC50 value of L-THP for contraction induced by BaCl2, KC1, 5-HT and His was 3 .5× 10-5mol/L , 4.5 × 10-5mol/L , 2.5×10-3 mol/L and 8.9× 10-5mol/L respectively. It was showed that sensibility of several agonists to inhibition by L-THP was correlated with dependence of extracellular Ca2+. The potencies of L-THP on anti-KCl and anti-5-HT actions were similar. The results suggested that LTHP possesses anti-calcium and anti-5-HT action on guinea pig trachea.

关 键 词：L-THP 激动剂 气管 药理 

分 类 号：R965.1[医药卫生—药理学]