3,6—[二甲氨基]—二苯骈碘杂六环枸橼酸盐对家兔血小板功能cAMP水平的影响  

EFFECT OF 3, 6-DIMETHAMIDODIBENZOPYRIODONIUM CITRATE ( IHC-65 ) ON PLATELET FUNCTION AND cAMP LEVEL IN RABBITS

作　　者：邱培伦[1] 吴基良[2] 陈淑英[3] 

机构地区：[1]西安医科大学药理学教研室,西安710033 [2]湖北医学院咸宁分院药理教研室,437100 [3]兰州大学化学系,730000

出　　处：《中国药理学通报》1990年第3期171-174,共4页Chinese Pharmacological Bulletin

摘　　要：3,6—[二甲氨基]—二苯骈碘杂六环枸橼酸盐(IHC—6^(5))在体外明显抑制ADP、花生四烯酸和胶原诱导的血小板聚集,对这些诱导剂的抑制作用无明显的选择性,IC_(50)分别为:51.9,55.1和57.4μmol/L,同时促进ADP、花生四烯酸诱导血小板聚集的解聚,减慢胶原诱导血小板聚集的速度,延长聚集潜伏期。其效应与剂量间呈现依赖关系。IHC-65也明显抑制胶原诱导的血小板5—羟色胺的释放,但对血小板内cAMP的水平无明显影响。结果提示:IHC—65是一个非选择性的血小板功能抑制剂,作用机理可能与抑制血小板释放反应及钙拮抗作用等有关,并非通过升高血小板内cAMP水平而发挥作用。IHC-65 was found to be a potent inhibitor of platelet function . It inhibited platelet aggregation induced by threshold concentration of ADP, arachidonic acid and collagen with dose-dependent manner in vitro, and at 96μmol/L, AIR ( aggregation inhibition rate,) were 71.56, 66.93 and 68.47% respectively. IHC-65 inhibited platelet serotonin release induced by collagen,and at 96 μmol/L, release inhibition rate was 82.97%. IHC-65 did not influence cAMP level in platelet significantly. It is concluded that IHC-65 inhibited platelet aggregation and its action mechanism may be related to inhibition of serotonin release and to antagonizing Ca ++ .

关 键 词：钙通道阻断剂 血小板 CAMP IHC-65 

分 类 号：R965.1[医药卫生—药理学]