麦芽醇抗人红细胞膜氧化的研究  

THE ANTIOXIDANT ACTION OF MALTOL ON ERYTHROCYTE MEMBRANE

作　　者：冯立明[1] 蔺福宝 潘华珍[1] 张之南[1] 黄芬[2] 梁旭方[2] 

机构地区：[1]中国协和医科大学,北京100730 [2]中国科学院生物物理研究所,北京100730

出　　处：《中国药理学通报》1990年第4期224-227,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金

摘　　要：以红细胞为对象,研究麦芽醇药物对外加H_2O_2及氢过氧化枯烯的抗氧化作用。麦芽醇可防止H_2O_2诱导的溶血及膜蛋白因氧化产生的聚集。用化学发光法及自旋捕获法对其抗氧化机制进行了探讨。麦芽醇可能是一个有效的氧自由基清除剂。Maltol is a chemical derived from Chinese herb Panax Ginseng. The effect of maltol on hemolysis and hydroperoxidation of erythro-cytes induced by active oxygen radical is presented. Maltol could protect hemolysis induced by H2O2 in vitro. When erythrocyte membrane protein was exposed to butylhydroperoxide in vitro, membrane protein was polymerized, and membrane lipids were oxidized to hydroperoxide compound. These oxidative reactions could inhibited by maltol. The results showed that maltol might act as a scavenger of superoxide of hydroxy radical as demonstrated by biochemical method and ESR spin method。

关 键 词：红细胞膜 氧自由基 麦芽醇 

分 类 号：R977.9[医药卫生—药品]