三七皂甙对血管平滑肌α受体引起^(45)Ca外溢与内流的影响  

EFFECTS OF PANAX NOTOGINSENG SAPONlNS ON THE ^(43)CA-INFLUX AND EFFLUX INDUCED BY ACTIVATION OF α-1 ADRENOCEPTOR OF VASCULAR SMOOTH MUSCLE

作　　者：关永源[1] 陈克敏[1] 孙家钧[1] 关超然 Daniel E E 

机构地区：[1]中山医科大学药理教研组,广州510089 [2]Dept.of Biomedical Sciences,McMaster University Hamilton,Ontario,Canada

出　　处：《中国药理学通报》1990年第4期229-231,共3页Chinese Pharmacological Bulletin

基　　金：卫生部基金;The Heart and Stroke Foundation of Ontario

摘　　要：在血管平滑肌,三七总皂甙明显减少苯肾上腺素引起的^(45)Ca内流量,不影响高钾引起的^(45)Ca内流;而硝苯吡啶几乎完全阻断后一种的^(45)Ca内流。三七总皂甙不抑制^(45)Ca外溢。结果表明,三七总皂甙能特异阻断血管平滑肌α受体操纵的Ca^(2+)通道而不影响胞内Ca^(2+)释放过程。In the vascular strip experiments, it was suggested that the panax notoginseng saponins ( PNGS ) could inhibit extracellular calcium ion entry through blocking receptor-operated calcium channel (ROC) . In the present study, PNGS did not affect the 45Ca-efflux induced by phenylephrine and significantly inhibited the 45Ca-influx induced by phenylephrine without any effect on 45Ca-influx induced by 100 mmol/L KCL which was significantly inhibited by nifedipine. These results are consistant with the results from the function studies in vascular smooth muscle and suggest that PNGS particularly block ROC, but not voltage-operated calcium channel.

关 键 词：三七皂甙 血管平滑肌 ^45ca内流 

分 类 号：R972.9[医药卫生—药品]