N-乙酰半胱氨酸在重度COPD患者的疗效观察  

Observation on Curative Effect of N-acetylcysteine in Patients with Severe COPD

作　　者：林杰[1] 陈建永[1] 林焕雄[1] 

机构地区：[1]广东省潮州市中心医院呼吸内科,广东潮州521000

出　　处：《临床医学工程》2012年第5期723-724,共2页Clinical Medicine & Engineering

基　　金：广东省医学科研基金(A2010173)

摘　　要：目的观察N-乙酰半胱氨酸治疗重度COPD的疗效。方法将80例重度COPD患者随机分成两组,对照组吸入沙美特罗/氟替卡松及噻托溴铵,治疗组在此基础上应用N-乙酰半胱氨酸,疗程1年,观察肺功能变化及急性加重次数。结果治疗组肺功能改善较明显,急性加重次数减少。结论 N-乙酰半胱氨酸可改善重度COPD患者的肺功能,减少急性加重次数。Objective To observe the curative effect of N-acetylcysteine for severe COPD patients. Methods 80 patients with severe COPD were randomly divided into two groups. The control group received salmeterol/fluticasone （50μg/500 μg） and tiotropium bromide for inhalation, and the treatment group received additional N-acetylcysteine. The lung function and number of exacerbation were observed. Re, sults The lung function improved obviously in treatment group compared with control group, and the frequency of exacerbation declined. Conclusions N-acetylcysteine is effective for improving lung function and reducing the frequency of exacerbations in patients with COPD.

关 键 词：慢性阻塞性肺疾病(COPD) N-乙酰半胱氨酸 抗氧化治疗 

分 类 号：R562[医药卫生—呼吸系统]