茜草双脂和S-2-(3-氨丙基胺)乙基硫代磷酸对人多形核白细胞吞噬作用中化学发光和电子顺磁共振的影响  

Effect of rubidatum and aminopropylaminoethylthiophos-phoric acid on the chemiluminescence and ESR of human polymorphonuclear leukocytes

作　　者：康鑫 方允中[1] 李小杰[2] 赵保路[2] 侯京武[2] 忻文娟[2] 

机构地区：[1]放射医学研究所,北京100850 [2]中国科学院生物物理研究所,北京100080

出　　处：《中国药理学与毒理学杂志》1990年第4期251-254,共4页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金;编号3870789

摘　　要：应用化学发光法和电子顺磁共振自旋捕集技术观察茜草双脂和WR2721对人多形核白细胞(PMN)受刺激剂PMA刺激后产生的氧自由基的清除作用。结果表明茜草双脂和WR2721对人PMN受PMA刺激后产生的氧自由基有较明显的清除作用,茜草双脂对水溶液体系中的O_2和~·OH的清除百分率分别为52.8与33.4,WR2721对水溶液体系O_2和~·OH的清除百分率分别为14.5与42.6。By using chemiluminescence method and ESR spin trapping technics,the effects of rubidatum,aminopropylaminoethylthiophosphoric acid(WR2721)and other substances on human polymorphonuclear leukocytes(PMN)stimulated by PMA were studied.The results showed that rubidatum,WR2721,bovine erythrocyte SOD and NaN3 could decrease the relative intensity of chemiluminescence,and give scavenging effect on oxy-gen radicals produced by PMA-stimulating PMN,but NaN3 did not.The percentages of the elimination of O2 and OH by rubidatum were found to be 52.82% and 33.38%,whereas those by WR2721,14.47% and 42.64%,respectively.

关 键 词：茜草双酯 WR2721 氧自由基 

分 类 号：R979.6[医药卫生—药品]