FcγRⅡ与儿童自身免疫性疾病  

FcγRⅡ and Autoimmune Diseases in Children

作　　者：綦巧雯[1] 林明祥[1] 

机构地区：[1]中山大学附属汕头医院儿科,广东汕头515031

出　　处：《实用儿科临床杂志》2012年第9期706-708,共3页Journal of Applied Clinical Pediatrics

摘　　要：与IgG的Fc段结合的Fcγ受体(FcγR)在体液免疫与细胞免疫的联系中起重要作用。人类的FcγRⅡ包括兴奋性的FcγRⅡA和FcγRⅡC,以及抑制性的FcγRⅡB。大量研究表明,FcγRⅡ的表达和基因多态性与多种自身免疫性疾病的易感性密切相关,如SLE类风湿性关节炎及特发性血小板减少性紫癜等,而针对FcγR的靶向治疗将成为治疗自身免疫性疾病的重要手段。A group of receptors binding the Fc region of immunoglobulin G （ IgG）, Fc gamma receptors （ FcγR）, provides important links between tile humoral and cellular immune responses. Human FcγR Ⅱ contains activating FcγR Ⅱ A and FcγR Ⅱ B, and inhibitory FcγR （ Fc-cR Ⅱ B）. Many studies suggested that expression of FcγRs and polymorphism of FcγR gene are associated with affectability of autoimmune disease, such as systemic lupus erythematosus, rheumatoid arthritis and idiopathic thrombocytopenie purpura. Targeted therapy to FcγR will be an important therapeutic intervention of autoimmune disease.

关 键 词：免疫球蛋白G FcγⅡ受体 自身免疫性疾病 

分 类 号：R725.9[医药卫生—儿科]