阿托伐他汀钙对高血压病患者血压变异性影响研究  

The effects of atorvastatin calcium on blood pressure variability in patients with hypertension

作　　者：李珂[1] 葛正庆[1] 周传堃[1] 安闽生[1] 李沂[1] 杜荣生[1] 

机构地区：[1]成都大学附属医院心血管内科,四川成都610081

出　　处：《四川医学》2012年第5期754-757,共4页Sichuan Medical Journal

摘　　要：目的以高血压患者为研究对象,探讨他汀类药物对其血压变异性的影响。方法将80例单纯高血压患者分为两组。A组(他汀组):43例,在降压的基础上给予阿托伐他汀;B组(对照组):37例,单纯给予降压药物治疗。血压达标后,分别对其进行24h动态血压监测。收集其BPV长时变异性指标,之后进行对比分析,以探讨他汀对高血压患者BPV产生的影响。结果与B组相比较,A组高血压病患者血压变异性较小,差异均有统计学意义,P<0.05,A组患者血浆LDL-C较低,P<0.05。结论对于单纯高血压病患者,他汀类药物在降低患者血脂的同时可明显降低其血压变异性,从而降低靶器官损害和心血管事件。Objective To investigate into the effects of the statins on blood pressure variabihty in patients with hypertension. Methods 80 cases of pure hypertension were divided into two groups. Group A （ statin group） ： 43 cases were given atorvastatin on the basis of antihypertensive therapy; Group B （control group） ： 37 cases were simply given antihypertensive drugs. All the patients were conducted the 24-hour ambulatory blood pressure monitoring after their blood pressure was up to the standards. The effects of the gtatins have on the BPV were investigated by colleting the long-term variability indexes which were analyzed comparatively then in patients with hypertension. Results The blood pressure variability of patients with hypertension in group A is smaller than that in group B, and the differences were significantly （P 〈 0. 05 ）. The levels of plasma LDL-C in group A were lower than those in group B （P 〈 0. 05）. Conclusion In patients with pure hypertension, the statins not only reduce the levels of serum hpid but also lower the blood pressure variability significantly, and thereby ease the target organ damage and reduce the cardiovascular events.

关 键 词：高血压病 阿托伐他汀钙 血压变异性 

分 类 号：R544.1[医药卫生—心血管疾病]