P-Phos-钯络合物催化吡啶硼酸的Suzuki偶联反应研究  

Diphosphane-Based Catalyst for the Palladium-Catalyzed Suzuki Cross-Coupling Reaction of Pyridylboronic Acids

作　　者：付兴丽[1] 

机构地区：[1]广西工业职业技术学院,广西南宁530001

出　　处：《企业科技与发展》2012年第6期26-28,共3页Sci-Tech & Development of Enterprise

基　　金：2012年广西教育厅科研处课题"水相中钯催化吡啶硼酸的Suzuki反应研究"阶段性成果

摘　　要：将双齿膦配体P-Phos应用于钯催化的3-吡啶硼酸的Suzuki反应中,通过对溶剂和碱等反应条件的考察,确定了最佳的催化条件,并对一系列底物进行了普适性拓展。实验表明,该催化剂对大多数卤代芳烃底物起到了良好的催化效果,并且可以实现惰性底物氯代芳烃与吡啶硼酸的高效偶联,产率高达99%。A highly active catalyst system derived from PdC12 and 2 2＇,6,6＇-tetramethoxy-4,4＇-bis（diphenylphosphanyl） -3,3＇-bipyridine（P-Phos） has been developed for the Suzuki cross-coupling reaction of pyridylboronic acid with a variety of arylhalides in good to excellent yields,even in the presence of hindered and functional groups.In addition,P-Phos also exhibites high activity in the palladium-catalyzed Suzuki reaction of 2,6-dimethoxypyridylboronic acid in excellent yields wita fast rate.The steric and electronic effects of the P-Phos-palladium complex to this cross-coupling reaction were also discussed.

关 键 词：SUZUKI反应 吡啶硼酸 P-Phos 氯化钯 

分 类 号：O643.32[理学—物理化学]