海洛因成瘾者反馈相关负波研究  

Feedback related negativity event-related potentials in heroin addicts

作　　者：林彬[1] 钱若兵[1] 傅先明[1] 韩晓鹏[2] 张浩 胡文富[1] 伊涛[1] 魏祥品[1] 牛朝诗[1] 汪业汉[1] 

机构地区：[1]安徽医科大学附属省立医院神经外科,合肥230001 [2]安徽省立体定向神经外科研究所神经心理室 [3]安徽省戒毒康复中心

出　　处：《中华脑科疾病与康复杂志（电子版）》2011年第2期32-35,共4页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

基　　金：国家自然科学基金(30670683;30973084);安徽省自然科学基金(070413264X;11040606M167);安徽省卫生厅医学科研课题(09B137)

摘　　要：目的探讨海洛因成瘾者结果评价过程中反馈相关负波(FRN)与冲动性行为的相关性。方法运用神经心理学实验范式,对海洛因成瘾组(HA组)和健康对照组(HC组)在执行爱荷华赌博任务(IGT)时同步进行事件相关电位(ERP)描记,数据采集后分析比较两组被试者FRN的波幅和潜伏期,并与冲动性量表(BIS)的测评结果作Pearson相关分析。结果 HA组BIS评分和选择高频惩罚纸牌数[(74.26±10.62)张,(167.81±26.71)张]高于HC组[(63.67±8.41)张,(143.36±23.67)张],差异有统计学意义(t=-3.25,-3.60,P均<0.05);两组被试IGT中结果评价中均出现明显的FRN的波形,其中HA组FRN的波幅高于HC组,差异有统计学意义[HC为(8.13±2.17)μV,HA为(10.62±1.91)μV;t=-5.37,P<0.05,而潜伏期差异无统计学意义[HC为(282.64±36.53)ms,HA为(268.45±40.91)ms;t=1.51,P>0.05],且两组被试FRN波幅均与其BIS评分呈正相关(r=0.77,0.61,P均<0.05)。结论海洛因成瘾者冲动性行为与FRN具有相关性,提示海洛因成瘾者的结果评价能力下降,可能是成瘾行为的产生及维持的原因之一。Objective To investigate the relationship between !mpulsive decision-making behaviors and the feedback related negativity （FRN） event-related potentials in heroin addicts. Methods Using the paradigms for psychological experiment, patients both in heroin addiction group （HA group） and health control group （HC group） performed Iowa gambling task （IGT） and underwent inspection of electroeneephalography simultaneously. Following the data collection, amplitude and latency of FRN between the two groups were compared, and then analyzed the relationship between amplitude of FRN and the results of barratt impulsiveness scale （ BIS-11 ） respectively. Results Compared to HC group, BIS score as well as the numbers of high frequency loss cards were significantly higher in HA group [ HC ： （63.67 ± 8.41 ） pieces, （ 143.36 ± 23.67 ） pieces ; HA ： （74.26 ± 10.62 ） pieces, （ 167.81 ± 26.71 ） pieces ; t = - 3.25, - 3.60, P 〈 0.05 for both ] , while both the two groups had visible waveforms of FRN, the amplitude was markedly higher in HA group [ HC ： （8. 13 ±2. 17 ） μv, HA： （ 10.62 ± 1.91 ）IxV; t = -5.37, P 〈 0. 05 ], but no statistical difference was found in latency of these two groups[ HC： （282.64±36.53）ms, HA： （268.45 ±40.91）ms;t = 1.51, P 〉0.05], and the amplitude of FRN were positively associated with BIS score in both two groups （r = 0.77, 0.61, P 〈 0.05 for both）. Conclusions Impulsive decision-making behaviors may associate with FRN, suggests that the capability of outcome evaluation is reduced in heroin addicts. It may partly contribute to both the addiction and relapse of heroin addiction.

关 键 词：事件相关电位 心理学 反馈 冲动行为 海洛因依赖 

分 类 号：R749.6[医药卫生—神经病学与精神病学]