新疆地区皮肤瘙痒症与西北燥证病证相关性分析  

Analysis on the relationship between prurituscutanea and Northwest Dryness Syndrome in Xinjiang region

作　　者：王燕 周铭心[2] 

机构地区：[1]新疆维吾尔自治区中医医院新药临床试验机构,乌鲁木齐830000 [2]新疆医科大学,乌鲁木齐830000

出　　处：《中华中医药杂志》2012年第6期1534-1537,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金资助项目(No.30860349);新疆维吾尔自治区自然科学基金资助项目(No.200821135)~~

摘　　要：目的:揭示新疆地区皮肤瘙痒症与西北燥证的病证联系,为从异病同治角度制定新疆地区皮肤瘙痒症防治策略提供流行病学依据。方法:采用病例对照研究设计,收集77例皮肤瘙痒症病例组,155例无病对照组,对两组西北燥证罹患率及积分进行比较;对病例组病情和临床辨证证情分别与西北燥证证情作病证切合指数分析及典型相关分析,探求二者之间病证关联性。结果:①皮肤瘙痒症组西北燥证罹患率为49.35%,对照组为24.52%,病例组高于对照组(χ2=14.404,P<0.01)。②病例组西北燥证总积分高于对照组(P<0.01)。其中病例组主证肺卫孔窍皮肤燥证与兼证肺心脾风火燥证、心肾阴虚证均高于对照组(P<0.05),尤以前二者明显。③皮肤瘙痒症病情与肺心脾风火燥证(fi=0.30,P<0.01)有较强关联度,其余各证fi均无统计学意义。④典型相关分析:第一典型变量r1=0.6972(P<0.01)。皮肤瘙痒症因变量组血虚风燥证载荷量最大(0.6835),自变量组肺心脾风火燥证载荷量(0.7029)最大。结论:①西北燥证是新疆地区皮肤瘙痒症患者的危险因素,并以肺心脾风火燥证为突出临床表现。②皮肤瘙痒症病情与西北燥证兼证3肺心脾风火燥证关联度最强。③皮肤瘙痒症临床证候血虚风燥证与肺心脾风燥证相关性最强。Objective： Explore the pathogenesis of contact between Northwest Dryness Syndrome and prurituscutanea to provide the epidemiological evidence for setting the development strategy for the prevention and treatment of prurituscutanea in Xinjiang region. Methods： By applying methods of philology analysis and clinical epidemiology, on the basis of case-control, disease group （77 cases） and control group （155 cases） were set up to compare the attack rate of Northwest Dryness Syndrome （NDS） and NDS integration in disease group and control group. Explore the pathogenesis contact in prurituscutanea and NDS by applying correlation analysis and canonical correlation analysis. Results： （!）The attack rate of NDS in disease group （49.35%） was higher than control group （24.52%） （;（2=14.404, P〈0.01）. （2）The total integration of NDS in Prurituscutanea group was higher than control group （P〈0.01）. There was obvious difference on the NDS integrations of main, lung defensive-orifices-skin dryness syndrome and lung-heart-spleen wind-fire dryness syndrome, and yin deficiency syndrome in disease group and control group. （3） The illness status of prurituscutanea was only correlated with the lung-heart-spleen wind-fire dryness syndrome （f=0.30, P 〈 0.01） but has no statistic significant with other syndromes. （4）Canonical correlation analysis： the first typical variable r1=0.6972 （P〈0.01）. The load of the blood deficiency and wind dryness syndrome was the largest value （0.6835） in dependent variable group. The load of the lung-heart-spleen wind-fire dryness syndrome was the largest value （0.7029） in independent variable group. Conclusion： （1）The northwest dryness syndrome, with the lung-heart-spleen wind-fire dryness syndrome as a prominent feature, is one of risk factors and common accompanying status for prurituscutanea in Xinjiang Uygur Autonomous Region. （2）There is a strong correlation between the illness status of prurituscutanea and the lung-hea

关 键 词：皮肤瘙痒症 西北燥证 关联性 

分 类 号：R275[医药卫生—中医皮科]