非肥胖多囊卵巢综合征患者网膜脂肪PPARγ_2 mRNA表达及与IR的关系  

Expression of peroxisome proliferator-activated receptor gamma 2 in omental adipose tissue of nonobese polycystic ovary syndrome subjects and its relationship with insulin resistance

作　　者：李艳[1] 谭丽[1] 

机构地区：[1]郑州大学第二附属医院,郑州450014

出　　处：《山东医药》2012年第19期43-45,共3页Shandong Medical Journal

基　　金：河南省省级医学高新技术发展扶持项目(200803060)

摘　　要：目的探讨过氧化物酶体增殖物激活受体γ2(PPARγ2)基因在非肥胖多囊卵巢综合征(PCOS)患者网膜脂肪组织的表达水平与胰岛素抵抗(IR)的相关性。方法选取非肥胖PCOS患者(观察组)11例和非PCOS患者18例(对照组),采用RT-PCR法检测两组网膜脂肪组织PPARγ2mRNA表达水平,测定空腹血糖、空腹胰岛素(FINS),计算稳态模型胰岛素抵抗指数(HOMA-IR)。结果观察组HOMA-IR明显高于对照组,P<0.01;余指标比较无统计学差异。相关性分析示,PPARγ2 mRNA表达水平与FINS、HOMA-IR等均无相关性。结论非肥胖P-COS患者网膜脂肪组织PPARγ2 mRNA的表达水平与IR无明显相关性。Objective To investigate the expression of peroxisome proliferator-activated receptor γ2 （ PPARγ2 ） in omental adipose tissue of nonobese polycystic ovary syndrome （PCOS） subjects and its relationship with insulin resistance （IR）. Methods Eleven nonobese PCOS subjects （observation group）and eighteen non-PCOS patients （control group） were chosen to detect the PPAR3＇2 mRNA expression level of omental adipose tissue by RT-PCR, fasting plasma glucose （FPG） and fasting plasma insulin （FINS） were measured to calculate homeostasis model insulin resistance index（ HOMAIR）. Results The level of HOMA-IR in observation group were higher than that in control group （P 〈 0.01 ） ; while the other parameters had no statistically significant difference. The correlation analysis showed that the expression level of PPARγ2 mRNA had no correlation with FINS and HOMA-IR. Conclusions The expression level of omental adipose tissue PPARγ2 mRNA had no correlation with insulin resistance in nonobese PCOS subjects.

关 键 词：多囊卵巢综合征 脂肪组织 过氧化物酶体增殖物激活受体γ2 胰岛素抵抗 

分 类 号：R711.75[医药卫生—妇产科学]