Asymmetric transfer hydrogenation of ketones catalyzed by nickel complex with new PNO-type ligands  

作　　者：Zhen Rong Dong Yan Yun Li Shen Luan Yu Guo Song Sun Jing Xing Gao 

机构地区：[1]State Key Laboratory for Physical Chemistry of Solid Surfaces,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China [2]Guangxi Research Institute of Chemical Industry,Nanning 530001,China

出　　处：《Chinese Chemical Letters》2012年第5期533-536,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No21173176);the Natural Science Foundation of Guangxi Province of China(No0991016)for the financial support of this work

摘　　要：The new polydentate mixed-N,P,O chiral ligands have been synthesized by the condensation of bis（o-formylphenyl）- phenylphosphane and R-phenylglycinol in CHCl_3,and fully characterized by IR,NMR and EIMS spectra.These ligands were employed with a simple Ni complex Ni（PPh_s）_2Cl_2 in situ as catalytic systems for asymmetric transfer hydrogenation of ketones,and the corresponding optical alcohols were obtained with up to 84%ee under mild conditions.The new polydentate mixed-N,P,O chiral ligands have been synthesized by the condensation of bis（o-formylphenyl）- phenylphosphane and R-phenylglycinol in CHCl_3,and fully characterized by IR,NMR and EIMS spectra.These ligands were employed with a simple Ni complex Ni（PPh_s）_2Cl_2 in situ as catalytic systems for asymmetric transfer hydrogenation of ketones,and the corresponding optical alcohols were obtained with up to 84%ee under mild conditions.

关 键 词：Nickel complex NPO-type ligand Asymmetric transfer hydrogenation KETONES 

分 类 号：O621.34[理学—有机化学] TQ463.53[理学—化学]