Antifungal and cytotoxic substances from the stem barks of Desmos chinensis  

作　　者：Monchanok Tuntipaleepun Suda Chakthong Chanita Ponglimanont Patimaporn Plodpai Supayang P.Voravuthikunchai 

机构地区：[1]Department of Chemistry,Faculty of Science,Prince of Songkla University,Hat Yai,Songkhla 90112,Thailand [2]Natural Products Research Center,Faculty of Science,Prince of Songkla University,Hat Yai,Songkhla 90112,Thailand [3]Department of Microbiology,Faculty of Science,Prince of Songkla University,Hat Yai,Songkhla 90112,Thailand

出　　处：《Chinese Chemical Letters》2012年第5期587-590,共4页中国化学快报（英文版）

基　　金：supported by Department of Chemistry,Faculty of Science,Prince of Songkla University

摘　　要：Isounonal-7-methyl ether（1） and chinendihydrochalcone（2） together with 8 known compounds were isolated from the stem barks of Desmos chinensis.Their structures were determined on the basis of spectroscopic data.Compound 2 exhibited cytotoxic activity against MOLT-3 cancer cell line（IC_（50） 7.16μg/mL） and antifungal activity against Pyricularia oryzae and Rhizoctonia solani with MIC values of 15.6 and 31.2μg/mL,respectively.Isounonal-7-methyl ether（1） and chinendihydrochalcone（2） together with 8 known compounds were isolated from the stem barks of Desmos chinensis.Their structures were determined on the basis of spectroscopic data.Compound 2 exhibited cytotoxic activity against MOLT-3 cancer cell line（IC_（50） 7.16μg/mL） and antifungal activity against Pyricularia oryzae and Rhizoctonia solani with MIC values of 15.6 and 31.2μg/mL,respectively.

关 键 词：DIHYDROCHALCONE Desmos chinensis Cytotoxic activity Antifungal activity 

分 类 号：S567.19[农业科学—中草药栽培]