158株金黄色葡萄球菌耐药性分析  

Analysis of drug resisitance in 158 strains of Staphylococcus aureus

作　　者：武超[1] 晏开力[2] 戴媛媛[3] 

机构地区：[1]武警安徽总队医院检验科,合肥230041 [2]安徽省疾病预防控制中心,合肥230001 [3]安徽省立医院检验科,合肥230001

出　　处：《武警医学》2012年第5期381-382,385,共3页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的了解住院患者感染的金黄色葡萄球菌(methicillin sensitive staphylococcus aureus,MSSA)对常用抗生素的耐药情况,以指导临床合理使用抗生素。方法应用VITEK32微生物自动鉴定分析系统,采用K-B法对2009-03至2011-10临床各科室分离的158株MSSA进行药物敏感性试验,并对其药敏结果进行统计分析。结果 158株MSSA中耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus,MRSA)96株,占60.76%,对青霉素G、氨苄西林100%耐药,对万古霉素100%敏感;对甲氧西林敏感MSSA,占39.24%,对青霉素G、氨苄西林耐药率分别为69.35%和67.74%,对利奈唑胺、喹努普汀/达福普汀和万古霉素100%敏感。结论 MSSA是临床感染的主要病原菌之一,分析MSSA耐药情况,可以指导临床合理选用抗生素。Objective To study the resistance of clinically - isolated Staphylococcus aureus to antimicrobial agents so as to fa- cilitate the rational use of antibiotics. Methods The pathogenic bacteria were evaluated by VITEK32. Drug susceptibility test was car- ried out by K - B method. The results of 158 strains of Staphylococcus aureus were analysed by WHONET. Results 96 strains of MR- SA were detected from 158 strains of Staphylococcus aureus ,which accounted for 60.76%. All the MRSA was resistant to penicillin and ampicillin but was sensitive to vancomycin. The resistance rate of MSSA to penicillin and ampicillin was 69.35% and 67.74% , re- spectively, and all the MSSA was sensitive to linezolid, quinupristin/dalfopristin and vancomycin. Conclusions Staphylococcus au- reus is one of the main pathogens of clinical infection. Analysis of drug resistance of Staphylococcus aureus can guide the clinical use of antibiotics.

关 键 词：耐甲氧西林金黄色葡萄球菌 耐药 药敏试验 

分 类 号：R446.1[医药卫生—诊断学]