TE-01静脉注射乳剂的制备及处方工艺优化  

Preparation and formulation optimization of TE-01 intravenous emulsion

作　　者：孙子杭[1] 胡凯莉[1] 胡红霞 徐玮 王燕飞[1] 涂亮星[1] 奉建芳[1] 

机构地区：[1]上海中医药大学穆拉德中药现代化研究中心,上海201203 [2]武汉同源药业有限公司研究所,武汉430074

出　　处：《中南药学》2012年第4期241-244,共4页Central South Pharmacy

摘　　要：目的制备TE-01静脉注射乳剂并进行处方工艺优化。方法采用高压均质方法制备TE-01乳剂,并通过正交设计优选TE-01静脉注射乳剂的最佳处方及其制备工艺。结果 TE-01静脉注射乳剂最佳处方及工艺为蛋黄卵磷脂含量1.2%,分散转速16 000r.min-1,均质压力550bar。结论高压均质法可以制备出性质稳定的TE-01乳剂。Objective To prepare and optimize the formulation and preparauon procedure of TE-01 intravenous emulsion. Methods High pressure homogenization method was used to prepare TE-01 intravenous emulsion. The formulation and preparation procedure of TE-01 intravenous emulsion were optimized by orthogonal experiments. Results The optimal formulation consisted of 1.2 % lecithin phospholipids with the dispersion rate at 16 000 r . min-1 , and the homogenization pressure was 550 bar. Conclusion Stable TE-01 emulsion can be prepared by high pressure homogenization method.

关 键 词：TE-01 静脉注射乳剂 处方工艺优化 

分 类 号：TQ460.60[化学工程—制药化工]