蒙药扎冲十三味丸对大鼠急性血瘀模型血液流变学的影响  

Effect of traditional mongolian medicine garidi-13 pills on hemorheology in acute blood stasis rats

作　　者：韩瑞兰[1] 常福厚[1] 肖云峰[1] 王敏杰[1] 

机构地区：[1]内蒙古医学院药学院,呼和浩特010010

出　　处：《中南药学》2012年第4期266-268,共3页Central South Pharmacy

基　　金：内蒙古自治区科技厅自然科学基金资助项目(编号:20080404MS1207)

摘　　要：目的观察Gi13对大鼠急性血瘀模型血液流变学的影响。方法采用皮下注射0.1%盐酸肾上腺素复合冰水浴大鼠血瘀模型,各组大鼠用乌拉坦麻醉后腹主动脉取血,测定大鼠血液流变学各参数及血小板聚集功能等指标。结果 Gi13高、中剂量组均能显著降低急性血瘀模型大鼠低切变率(1s-1)全血黏度、中切变率(50s-1)全血黏度、血浆纤维蛋白原浓度、红细胞压积、血沉、红细胞聚集指数、血小板聚集率等指标(P<0.05)。结论 Gi13对大鼠急性血瘀模型血液流变学及血小板功能的异常变化有明显的改善作用。Objective To observe the effect of Garidi-13 pills on hemorheology in acute blood stasis rats. Methods The acute blood stasis rat model was established with subcutaneous injection of 0.1% adrenaline hydrochloride with ice water bath in 2 h. After anesthesia with urethane, blood was taken from the abdominal artery, and then its hemorheologi cal parameters, platelet aggregation and other indicators were measured. Results Both the high and medium dose groups of Gil3 pills significantly reduced the low （1 s 1 ）, and medium shear rate （50 s ~ ） of the blood viscosity, plas- ma fibrinogen concentration, hematocrit, erythrocyte sedimentation rate, erythrocyte aggregation index, and platelet aggregation rate （P 〈0.05） in acute blood stasis rats. Conclusion Gil3 pills can significantly improve the abnormalities of platelet function and hemorheology in acute blood stasis rats.

关 键 词：急性血瘀证 血液流变学 扎冲十三味丸 

分 类 号：R965[医药卫生—药理学]