广州管圆线虫感染小鼠后在其体内分布及小鼠组织病理学实验观察  

EXPERIMENTAL OBSERVATION ON THE DISTRIBUTION OF ANGIOSTRONGYLUS CANTONENSIS IN MICE AND HISTOPHATHOLOGY OF INFECTED MICE

作　　者：潘长旺[1] 梁韶晖[1] 凌洪博[1] 易维平 黄慧聪[1] 刘启真[1] 郑晓云[1] 金永国[1] 

机构地区：[1]温州医学院寄生虫学教研室,浙江温州325003 [2]温州市卫生防疫站

出　　处：《中国寄生虫病防治杂志》2000年第1期31-33,共3页Chinese Journal of Parasitic Disease Control

基　　金：浙江省卫生厅基金;温州市科委基金

摘　　要：为观察广州管圆线虫感染小鼠后在小鼠体内的分布及对小鼠的致病作用 ,以广州管圆线虫第三期幼虫人工感染实验小鼠 ,分批处死后 ,镜检并记录各部位虫体 ,同时进行组织病理学观察。结果感染不同时间后 ,小鼠肝、心、肺、脑、脊髓、肾、眼球、肌肉等部位均发现有幼虫寄生 ,其中脑、脊髓是广州管圆线虫的主要寄生部位。虫体寄生部位因虫体的机械作用和炎症反应而受损。In order to observe the distribution of Angiostrongylus cantonensis in mice and histopathology of infected mice, the mice were artificially infected with the third stage larvas of A. cantonensis that were isolated from Ampullaria gigas captured in Cangnan district, Zhejiang Province. The results indicated that larvas of A. cantonensis were found in liver, heart, lung, cerebrum, spinal cord, kidney, eyeball and muscle etc. of infected mice in different time after infection, cerebrum and spinal cord were probably the optimum positions for A. cantonensis to parasitize in mice. Some positions in which larvas parasitized were damaged by mechanical affection and inflammatory reaction. Besides, the migration and development of larvas of A. cantonensis in mice were preliminarily discussed.

关 键 词：广州管圆线虫 分布 组织病理学 小白鼠 

分 类 号：R532.102[医药卫生—内科学]