花椒油素对肺血栓及6-酮-前列腺素F_(1α)和血栓素B_2的影响  

Effects of Xanthoxylin on the Amount of 6-keto-prostaglandin F_( la) and Thromboxane B_2 in Mice with Pulmonary Thromboembolism

作　　者：金云海[1] 单春文[2] 程远远[2] 

机构地区：[1]第一军医大学药理教研室,广州510515 [2]暨南大学医学院第一附属医院药剂科,广州510630

出　　处：《中药新药与临床药理》2000年第2期88-90,共3页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：以胶原和肾上腺素混合液给小鼠 ,制造肺血栓模型 ,用放免法测定 6-酮 -前列腺素F1α ( 6-keto_PGF1α)和血栓素B2 (TXB2 )含量。结果表明 ,花椒油素 (Xanthoxylin ,XT ) 1 .0mg/kg,2 .0mg/kg,4 .0mg/kg和 8.0mg/kg使小鼠的存活率增加 2 8.6%～ 71 .2 % ;使 6_keto_PGF1α的产量提高 56.3 %～ 2 1 0 .8% ,使TXB2 的产量降低 2 1 .6%～ 56.8%。 6_keto_TGF1α与TXB2 的比值明显提高 ,对照组为 1 .1 5,药物组为2 .2 9,3 .1 3 ,5.53 ,8.2 6。体外实验证明 ,XT 0 .0 3 7μmol/L,0 .1 85μmol/L,0 .92 4 μmol/L,9.2 4 0 μmol/L显著地抑制血小板聚集和TXB2 产生 ,前者的抑制率为 2 2 .7%～ 55.3 % ,后者为 2 0 .5%～ 50 .7% ;但同时增加 6_keto_PGF1α的产量 ,提高率为 2 7.3 %～ 4 7.0 %。 6_keto_PGF1α与TXB2 比值 :对照组为 1 .2 3 ,药物组为2 .0 7,2 .4 4,3 .2 8,3 .85。Model mice with pulmonary thromboembolism were established by administration of mixture of collagen and adrenaline.Radioimmunoassay was used to detect the serum level of 6_keto_prostaglandinF la (6_keto_PGF la ) and thromboxane B 2(TXB 2).Results showed that xanthoxylin being at the concentration of 1.0 , 2.0 , 4.0 , 8.0mg/kg ,the survival rate of mice was increased by 28.6%～71.2% ,the amount of 6_keto_PGF la by 56.3%～210.8%,and the amount of TXB 2 by 21.6%～56.8% .The ratio of 6_keto_PGF la and TXB 2 was enhanced markedly,being 1.15 in the control group, and 2.29 , 3.13 , 5.53 and 8.26 in the medication groups respectively.In vitro,xanthoxylin in the dosages of 0.037 , 0.185 , 0.924 , 9.240 μmol/L significantly inhibited the aggregation of platelet and the production of TXB 2,with the inhibition rate of 22.7%～55.3% and 20.5%～50.7% respectively.Meanwhile the amount of 6_keto_PGF la was increased by 27.3%～～47.0% and the ration of 6_keto_PGF la and TXB 2 was also increased,being 1.23 in the control group,and 2.07 , 2.44 , 3.28 and 3.85 in the medication groups respectively.

关 键 词：花椒油素 药理学 肺血栓 血栓素B2 药物作用 

分 类 号：R285.5[医药卫生—中药学]