巴戟素对衰老大鼠空间学习记忆力的改善作用  

Improvement Effect of Bajishin on Spatial Learning and Memory Abiligy of Rats

作　　者：谭宝璇[1] 苏文[1] 陈洁文[1] 陈朝凤[1] 王勇[1] 李小英[1] 

机构地区：[1]广州中医药大学生理教研室,广州510405

出　　处：《中药新药与临床药理》2000年第2期95-97,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家中医药管理局课题 !(97L025)

摘　　要：用D -半乳糖化的方法制备大鼠衰老模型 ,通过Morris水迷宫测试 ,观察巴戟素对衰老大鼠空间学习记忆力的影响 ;应用海马脑片灌流技术 ,观察巴戟素对海马突触长时程增强 (LTP)的影响。结果显示 ,巴戟素能使衰老大鼠逃避潜伏期缩短 ;原平台象限游泳时间和 4 0cm环内游泳时间明显延长 ;原平台象限游泳路径百分比增加。还可显著增强海马脑片的LTP效应 ,并呈一定的量效关系。提示巴戟素可提高衰老大鼠的空间学习、记忆能力 。Senile rat model was induced by D_Galactose.The effect of Bajishin on spatial learning and memory ability of senile rats was observed by Morris Water Maze test and the effect of Bajishin on the long_term potentiation(LTP)of hippocampus synapse was observed by hippocampal slice perfusion technique.The results showed that the escape latency of senile rats was shortened,the proplateau quadrant and the 40cm circle swimming times lengthened,the proplateau quadrant swimming path percentage increased and the LTP effect of hippocampal slice increased significantly with an dose/effect relationship.It is suggested that Bajishin can improve spatial learning and memory ability of senily rats,and its mechanism may relate to the increase of LTP effect of hippocampal synapse transmission.

关 键 词：巴戟素 药理学 学习 记忆 海马脑片 疾病模型 

分 类 号：R285.5[医药卫生—中药学]