粘液水肿病人水负荷前、后水盐代谢激素的变化  

Study on the Metabolic Changes of Hormones Regulating Water and Electrolytes before and after Acute Water Loading in Myxedematous Patients

作　　者：刘晓民[1] 白耀[2] 郭芝生[2] 戴为信[2] 史轶蘩[2] 周学瀛[2] 

机构地区：[1]哈尔滨医科大学第一附属医院 [2]中国医学科学院协和医院

出　　处：《中国医学科学院学报》1990年第2期79-83,共5页Acta Academiae Medicinae Sinicae

摘　　要：在水负荷前,12例重症粘液水肿病人平均血浆抗利尿激素(AVP)高于正常组(n=5)但差别不显著(P>0.05),伴血浆心钠素(血浆ANP)明显升高(P<0.05);在水负荷后,病人组平均血浆渗透压降低,但平均血浆AVP不被水负荷抑制或抑制不全,伴水负荷的清除障碍。水负荷前、后病人组平均血浆ANP和血浆醛固酮(血浆Ald)均无明显波动,符合抗利尿激素不适当分泌增多综合征(SIADH)的改变。9例经甲状腺片替代治疗病人,当甲状腺功能恢复或接近于正常时,上述异常指标多数得到纠正。The average plasma AVP in 12 cases of patients with overt myxedema was higher than that of normal controls (n = 5) before water loading, though there was no significant difference (P>0.05). The plasma ANP levels were increased (P< 0.05). After water loading the average plasma osmolality level of patients was lower, and the mean plasma AVP concentration of patients was not suppressed after loading. A disturbance in water clearance was demonstrated. The mean levels of plasma ANP and aldosterone were not markedly changed in patients before and after loading. These observations coincide with the changes of SIADH. Most of the above blood parameters were improved along with thyroid function in 9 patients who were restored to normal after replacement with desiccated thyroid.

关 键 词：粘液水肿 抗利尿激素 心钠素 

分 类 号：R581.220.2[医药卫生—内分泌]