雷公藤总甙对大鼠生精作用及主要脏器的影响  

Effect of Glycosides of Tripterygium Wilfordii Hook on the Reproductive System and Major Organs of Male Rats

作　　者：卢清显 沈晓明 程凯[1] 陈啸梅[1] 薛社普[1] 

机构地区：[1]中国医学科学院基础医学研究所

出　　处：《中国医学科学院学报》1990年第3期203-207,共5页Acta Academiae Medicinae Sinicae

摘　　要：给大鼠每日喂服雷公藤总甙(TⅡ)10mg/kg 7、13周和20mg/kg 4、10周,结果其精子发生及曲细精管晚期精子细胞碱性核蛋白的替代和转换均受到明显抑制;附睾尾精子数目明显减少,残存精子畸变,头部膨大,头颈断裂,颈部断端高度卷曲;精子线粒体酶反应颗粒减少。心、肝及肾多种酶活性与对照组比较无明显差别,但3种组织的SDH及肾小管中的ACP显著增强,近曲小管刷状缘的ALP活性轻微减弱,提示3种主要器官的轻微改变是机体对TⅡ毒性的一种适应性反应。Spermatogenesis and turnover of basic nuclear protein synthesis in late elongated spermatids of rat testis were found to be significantly inhibited by glycosides of Tripterygium wilfordii Hook (TⅡ) at a daily dosage of 10 nig/kg for 7 or 13 weeks and 20mg/kg for 4 or 10 weeks. The number of spermatozoa in the epididymis was found to be reduced and the remaining spermatozoa deformed, showing head swelling, head and tail separation and severe curling of the middle piece. These changes differed from those effected by gossypol treatment. The formazan deposits of sperm mitochondrial enzyme reactions were also reduced, Activities of several enzymes in the heart, liver and kidney were not obviously affected, except for an enhancement of SDH activity in tissues of all 3 organs and ALP in renal tubules, with a slight decrease of ALP in the brush-borders of proximal renal tubules arising as an adaptation to TⅡ toxicity.

关 键 词：雷公藤总甙 抗生育作用 精子发生 

分 类 号：R979.21[医药卫生—药品]