血清非高密度脂蛋白脂固醇在冠心病合并高脂蛋白血症中的诊断意义  

Serum non-High Density Lipoprotein Cholesterol Level in the Diagnosis of the Coronary Heart Disease with Hyperlipoproteinemia

作　　者：王惠珍[1] 刘德文[1] 

机构地区：[1]山西医科大学生物化学教研室,山西省太原市030001

出　　处：《中国动脉硬化杂志》2000年第1期67-69,共3页Chinese Journal of Arteriosclerosis

摘　　要：为探讨非高密度脂蛋白胆固醇在冠心病合并高脂蛋白血症发病学中的作用及临床意义 ,从太原市 5 471名居民血脂分析中 ,选取 183名冠心病稳定期合并高脂蛋白血症患者 ,及 194名身体健康的正常体检者 ,分别测定血清甘油三酯、总胆固醇和高密度脂蛋白胆固醇 ,低密度脂蛋白胆固醇和极低密度脂蛋白胆固醇根据Friedewald公式计算 ,并按Frost法计算出非高密度脂蛋白胆固醇的含量。结果发现 ,冠心病合并Ⅱa和Ⅱb型高脂蛋白血症患者 ,其血清低密度脂蛋白胆固醇及非高密度脂蛋白胆固醇含量与正常组比较有显著性差异 (P <0 .0 0 1) ;而合并Ⅳ型高脂蛋白血症患者血清低密度脂蛋白胆固醇含量与正常组比较无差异 (P >0 .0 5 ) ,但非高密度脂蛋白胆固醇的含量显著高于正常组 ,差异有显著性统计学意义 (P <0 .0 0 1)。提示血清非高密度脂蛋白胆固醇含量变化在冠心病合并ⅡaⅡb及Ⅳ型高脂蛋白血症患者中具有诊断意义。Aim [WT5”BZ]To study whether serum non-high density lipoprotein cholesterol (nHDLC) level is related to coronary heart disease (CHD). [WT5”HZ]Methods [WT5”BZ]The triglyceride, total cholesterol and high density lipoprotein cholesterol in the serum of 183 patients with coronary heart disease with hyperlipoproteinemia and 194 healthy individuals were tested separately. The low density lipoprotein cholesterol and the very low density lipoprotein cholesterol were calculated according to Friedewald`s formula LDLC = TC - (HDLC + 0.458 TG) and the non-HDL Ccontent was calculated with Frost method. [WT5”HZ]Results [WT5”BZ]There was significant difference in serum low density lipoprotein cholesterol (LDLC) level and nHDLC level between the CHD with Ⅱa and Ⅱb patient group and control group (P<0.001). There was no significant difference in serum LDLC level between the CHD with Ⅳ patient group and control group (P>0.05), while serum nHDLC level was significantly higher in CHD with Ⅳ patient group than control group (P<0.001). [WT5”HZ]Conclusions [WT5”BZ] This article provides examples of the utility of non-HDL cholesterol concentrations in clinical medicine.

关 键 词：冠状动脉疾病 诊断 脂蛋白胆固醇 

分 类 号：R541.404[医药卫生—心血管疾病]