不稳定型心绞痛患者血清肌钙蛋白Ⅰ的变化  

Change of serum troponin Ⅰ in patients with unstable angina pectoris

作　　者：姜霞[1] 田凤石[1] 赵明[1] 张秀全 巩岩霞[1] 

机构地区：[1]天津公安医院,天津300050

出　　处：《中国中西医结合急救杂志》2000年第2期111-112,共2页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

摘　　要：目的 :对比观察不稳定型心绞痛与稳定型心绞痛患者血清中肌钙蛋白 (c Tn )升高与心脏事件的关系。方法 :对 5 0例不稳定型心绞痛患者 (U AP)、2 0例稳定型心绞痛患者及 2 0例健康人分别进行血清 c Tn 及肌酸激酶同工酶 (CK MB)测定 ,并观察住院期间心脏事件发生率。结果 :12 0例稳定型心绞痛患者 c Tn 定量为 (8.6 4± 3.12 )μg/ L ,CK MB值为 (14.5 0± 4.5 0 ) U / L ;U AP组 c Tn 定量为 (14.2 1± 4.2 6 )μg/ L ,CKMB值为 (16 .5 2± 5 .46 ) U / L ,c Tn 比较 P<0 .0 1,而 CK MB比较 P>0 .0 5。 2以 c Tn ≥ 10μg/ L为分界值 ,则 5 0例 U AP患者中 19例 c Tn 明显升高〔(16 .78± 4.5 2 ) μg/ L〕,同时测定 CK MB值为 (16 .82±4.2 1) U/ L;余 31例 c Tn 为 (9.12± 0 .18) μg/ L,其 CK MB值为 (16 .13± 4.5 0 ) U/ L;c Tn 比较 P<0 .0 1,而CK MB比较 P>0 .0 5。 3不稳定型心绞痛患者中 c Tn 升高组急性心肌梗死、心脏性猝死、顽固性心绞痛的发生率明显高于 c Tn 正常组。结论 :c Tn 对判断 UAP患者预后具有较高的预测价值。Objective:To observe the relationship between increased value of serum cardiac troponin Ⅰ( cTnⅠ ) and cardiac events in patients with unstable angina pectoris (UAP) and stable angina pectoris(SAP).Methods:Serum cTnⅠ and MB isoenzyme of creatine kinase(CKMB) were tested in 50 cases of UAP,20 cases of SAP and 20 cases of healthy persons.At the same time the incidences of cardiac events were observed in hospital.Results:①serum cTnⅠ value in SAP group was significantly lower than that in UAP group 〔(8 64±3 12)μg/L vs.(14 21± 4 26)μg/L ,P<0 01〕,but serum CKMB value in two groups were similar 〔(14 50±4 50)U/L vs.(16 52± 5 46)U/L ,P>0 05〕.②Serum cTnⅠ≥10 μg/L as the cutoff value,19 in 50 UAP patients were highly increased 〔(16 78±4 52)μg/L〕and the serum CKMB value was (16 82±4 21)U/L.31 in 50 UAP patients serum cTnⅠ and CKMB remained normal 〔(9 12±0 18)μg/L and (16 13±4 50)U/L respectively〕.cTnⅠ had significant difference in two groups (P<0 01),but CKMB had no difference(P>0 05).③The incidences of AMI and sudden cardiac death,incidence rate refractory angina pectoris were significant higher in the group of increased cTnⅠ than that of normal cTnⅠ in UAP.Conclusions:Serum cTnⅠ is a useful marker to predict the prognosis of UAP patients.

关 键 词：不稳定型心绞痛 肌钙蛋白Ⅰ 治疗 预后 

分 类 号：R541.4[医药卫生—心血管疾病]