抗心肌ADP/ATP载体对小儿心脏病的诊断价值  

The diagnostic value of autoantibody against myocardiac adenine nucleotide translocator in children with heart diseases

作　　者：张淑梅[1] 徐灵敏[2] 栾斌 刘松茂[3] 程秀永 皱丽萍 王棣华 

机构地区：[1]郑州市妇幼保健院,河南郑州450052 [2]河南医科大学第三附属医院小儿内科,河南郑州450052 [3]河南医科大学第一附属医院小儿内科,河南郑州450052

出　　处：《河南医学研究》2000年第1期46-47,共2页Henan Medical Research

基　　金：河南省重点科研攻关项目

摘　　要：目的 :探讨抗心肌ADP/ATP载体 (ANT)抗体对小儿心脏病的诊断价值。方法 :运用免疫印转法检测了 3 0例病毒性心肌炎 (VMC)、14例扩张型心肌型 (DCM) ,10例风湿性心脏病 (RHD)、2 2例先天性心脏病 (CHD)患儿血浆抗ANT水平。结果 :抗ANT抗体在VMC和DCM患儿中的阳性率显著高于RHD、CHD和NC三组研究对象 (P均 <0 .0 1)。抗ANT抗体诊断VMC和DCM的敏感性为 72 73 % ,特异性为 98 2 5 %。结论 :抗ANT抗体在小儿心脏病的鉴别诊断中有重要价值 。Objective: In order to explore the diagnostic value of autoantibody against myocardiac adenine nucleotide translocator(ANT) in children with heart diseases.Methods: The plasma anti-ANT in children with heart diseases,30 with viral myocarditis(VMC),14 with dilated cardiomyopathy(DCM),10 with rheumatic heart diseases(RHD),22 with congenital heart diseases(CHD),were studied with western blot.Results: The plasma level of anti-ANT in VMC and DCM group was significantly higher than not only those in the healthy group,but also in the RHD and CHD(All P<0.01 ).The diagnostic sensitivity and specifity of anti-ANT for VMC and DCM were 73% and 98%.Conclusion: The anti-ANT has important value for differential diagnosis in children with heart diseases.It can be taken as a specific marker for diagnosis of VMC and DCM in children.

关 键 词：心脏病 心肌炎 心肌疾病 抗体 诊断 儿童 

分 类 号：R725.41[医药卫生—儿科]