丁香挥发油对磷酸川芎嗪贴剂的经皮促渗作用  

Percutaneous Enhancement Function of Volatile Oil from Eugenia caryophyllata on Ligustrazine Phospate Patch

作　　者：罗红梅[1] 马云淑[1] 黄金娥[1] 张贵华[1] 康绍建 

机构地区：[1]云南中医学院药学院,昆明650500 [2]云南省食品药品检验所,昆明650000

出　　处：《中国实验方剂学杂志》2012年第11期40-43,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：云南省科技计划项目(2008CD152);国家自然科学基金项目(30960517)

摘　　要：目的:考察不同质量分数的丁香挥发油对磷酸川芎嗪贴剂的经皮促渗作用。方法:用改良Franz扩散池法,以氮酮为阳性对照,不含促渗剂的磷酸川芎嗪贴剂为阴性对照,考察含3%,5%,7%,10%的丁香挥发油对模型药磷酸川芎嗪经小鼠皮肤的促渗效果,采用HPLC测定磷酸川芎嗪的含量。结果:4种质量分数的丁香油对磷酸川芎嗪12 h平均累积渗透量(Q12)分别为3.030,4.066,1.845,1.205 mg.cm-2;其12 h时增渗倍数分别为1.54,2.06,0.96,0.62。与阴性对照组的Q12比较,5%丁香油与3%丁香油促渗作用显著。结论:3%,5%的丁香油能明显提高磷酸川芎嗪在贴剂中的渗透量,且促渗效果好。Objective： To investigate percutaneous penetration effect of different concentration of volatile oil from Eugenia caryophyllata on ligustrazine phosphate （LP）. Method： Modified Franz diffusion cell method was used, with azone as positive control, LP without penetration enhancers as negative control, penetration effect of 3% , 5% , 7% and 10% volatile oil from E. caryophyllata on LP through mouse skin were investigated, the content of LP was determined by HPLC. Result： Average cumulative permeation volume （Q12） of the 4 concentrations of volatile oil from E. caryophyllata on LP in 12 h were 3. 030, 4. 066, 1. 845 and 1. 205 mg·cm^-2, respectively; and enhancing rates （ER） in 12 h were 1.54, 2.06, 0.96 and 0.62, respectively. Compared with Q12 of negative control group, 5% and 3% volatile oil from E. caryophyllata had significantly enhancing effect. Conclusion： 3% and 5% volatile oil from E. caryophyUata could enhance permeation volume of LP through mouse skin obviously, and had great enhancing effect.

关 键 词：丁香挥发油 磷酸川芎嗪贴剂 经皮渗透 

分 类 号：R283.6[医药卫生—中药学]