疏肝理脾法联合热疗及动脉灌注化疗治疗晚期胰腺癌  

Treatment of Smoothing the Liver and Regulating the Spleen Combined with Hyperthermia and Intra-arterial Infusion Chemotherapy for Advanced Pancreatic Cancer

作　　者：韩冬[1] 李婵[1] 杨国旺[1] 张青[1] 杨中[1] 赵文硕[1] 王笑民[1] 

机构地区：[1]首都医科大学附属北京中医医院肿瘤科,北京100010

出　　处：《中国实验方剂学杂志》2012年第11期254-257,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨疏肝理脾法联合热疗及动脉灌注化疗治疗晚期胰腺癌的近期疗效。方法:我院住院治疗符合病例入选标准的65例晚期胰腺癌患者,随机分为治疗组(动脉灌注化疗加腹腔热疗、四逆散加减)31例和对照组(单纯动脉灌注化疗)34例,观察两组的近期疗效、疼痛评分、肝郁脾虚证积分、脾气虚证积分、毒副反应、体力状态评分。结果:治疗组与对照组比较,CR+PR+SD分别为85.71%,71.88%(P<0.05);疼痛控制CR+PR+MR分别为85.71%,62.5%(P<0.05);治疗组和对照组肝郁脾虚证证候积分分别为(10.81±4.09),(15.27±5.67)分,治疗组低于对照组(P<0.05)。结论:疏肝理脾中药联合热疗及局部动脉灌注化疗临床获益率高于单纯动脉灌注化疗。Objective： To investigate short-term effect of smoothing the liver and regulating the spleen treatment combined with hyperthermia and intra-arterial infusion chemotherapy for advanced pancreatic cancer. Method： Sixty in-patients with advanced pancreatic cancer meeting the inclusion criteria, were randomly divided into the treatment group with 28 patients （intra-arterial chemotherapy plus intraperitoneal hyperthermia with Sini Decoction） and the control group with 32 patients （intra-arterial chemotherapy alone）. Short-term effect, pain score, liver depression and spleen deficiency Syndrome points, spleen deficiency syndrome points, side effects, physical state score were observed. Result： The treatment group CR ＋ PR ＋ SD （85.71%） was higher than that in the control group （71.88%）, P 〈0.05. The treatment group pain control CR ＋ PR ＋ MR （85.71%） was higher than that in the control group （62.5%）, P 〈 0.05. Liver depression and spleen deficiency syndrome score in the treatment group and the control group was 10. 81±4.09 and 15.27 ±5.67 accordingly, and showed a statistics difference after intervention treatment than before, P 〈 0.05. Conclusion： Clinical benefit of smoothing the liver and regulating the spleen treatment combined hyperthermia and local intra-arterial infusion chemotherapy is higher than simple arterial infusion chemotherapy.

关 键 词：晚期胰腺癌 疏肝理脾 动脉灌入化疗 热疗 

分 类 号：R287[医药卫生—中药学]