虚证动物模型的研究现状  

Advanced Study on Animal Models with Deficiency Syndrome

作　　者：徐启华[1] 胡明华 马方励 彭博[1] 贺蓉[1] 李建荣[1] 

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]无限极中国有限公司,广州510180

出　　处：《中国实验方剂学杂志》2012年第11期307-312,共6页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目前文献报道的虚证动物模型包括气虚、血虚、阳虚和阴虚4种类型。在中医证候模型上,以扶正固本理论为指导研究中药的干预作用,对于阐述中医从整体出发、调动机体内在因素、提高机体抗病能力,以达到治疗虚证的目的具有重要意义。多年来经过学者们的积极探索,现已建立了40多类中医证候动物模型,但目前的虚证动物模型既有其特点,又存在一定的片面性。如何使动物模型更接近临床,已经成为当前虚证动物模型研制工作中的重大问题。由于反映扶正固本药物的综合干预作用多需要通过2种以上的虚证模型做出综合评价,因此为更全面了解虚证模型的制备及应用情况,就近年来虚证动物模型的制备方法、检测指标以及扶正固本药物在虚证动物模型上的应用情况进行综述,以期为虚证模型在药物研究方面的应用提供参考。Animal models with deficiency syndrome included four types like Qi deficiency,blood deficiency,Yang deficiency and Yin deficiency.Under direction of the strengthening the body resistance theory of traditional Chinese medicine（TCM） the research work on interfering effects of herbs on animal models with deficiency syndrome plays an important role.Up to now,forty kinds of animal models related to syndrome and sign of TCM have been established,which have brought a wide application in the research work.But,on the other hand,some limitations and disadvantages existed.The key point lies in whether the animal models concerning syndrome and sign of TCM can be consistent with clinical symptoms.The interfering effects of Chinese herbs with strengthening the body resistance functions need be comprehensively evaluated in at lest two kinds of the animal model.In order to understand current status about animal models with deficiency syndrome and to provide reference for researchers of TCM area,modeling methods of animal model with deficiency syndrome,observation indexes and application of Chinese herbs in the models were reviewed.

关 键 词：扶正固本 气虚 血虚 阳虚 阴虚 动物模型 

分 类 号：R285.5[医药卫生—中药学]