壳聚糖三维材料的制备及其应用研究进展  

Progress in the Preparation of Three-dimensional Chitosan Material

作　　者：姚远[1] 胡巧玲[2] 谌凯[2] 

机构地区：[1]合肥工业大学化工学院,合肥230009 [2]浙江大学生物医用大分子研究所,杭州310027

出　　处：《科技通报》2012年第5期1-8,13,共9页Bulletin of Science and Technology

基　　金：国家重点基础发展研究计划资助项目(973计划)(2011CB606203;2009CB930104);中国博士后基金(20100480085);国家自然科学基金(21104067)

摘　　要：在生物材料的研究领域中,有关壳聚糖材料的制备与应用研究越来越受到重视,由于壳聚糖特殊的结构与性能导致壳聚糖三维材料的制备极其困难。本文着重介绍近年来壳聚糖三维材料制备研究的进展,重点是为三维壳聚糖无机复合材料、三维壳聚糖磁性功能材料、三维壳聚糖增强材料、三维壳聚糖仿生材料以及三维壳聚糖组织工程支架材料的研究进展及各材料的性能与应用方向;展望了壳聚糖三维材料的发展前景,特别是提高壳聚糖三维材料的力学性能以及在人体内环境下力学性能的耐衰减能力,在生物可降解骨折内固定材料与生物可降解骨组织工程的应用上起着决定作用,将是未来几年壳聚糖三维材料研究的重点和突破口。The preparation and application Of chitosan-based biomaterials had been highly valued in recent years. Be- cause of the unique structure and property of chitosan, the preparation of three-dimensional chitosan-based materials was very hard. This paper emphasized on recent progress on the preparations of three-dimensional chitosan-based materials, including three-dimensional chitosan-inorganic composite materials,three-dimensional chitosan magnetic materials, three- dimensional chitosan reinforced materials,three-dimensional chitosan biomimetic materials and three-dimensional chi- tosan scaffold materials for tissue engineering. Besides, the developing trend of three-dimensional chitosan-based materi- als was forecasted. According to the related reports, improving both the dry mechanical properties and wet mechanical properties of three-dimensional chitosan-based materials was vital for their applications in bone internal fixation and bone tissue engineering. Therefore, it will be the focus and breakthrough of future researches.

关 键 词：壳聚糖 羟基磷灰石 骨折内固定 生物医用材料 

分 类 号：O636.1[理学—高分子化学]