阿维菌素缓释固体分散体的制备及其性能研究  

Preparation and Properties of Controlled Release Solid Dispersion of Avermectin

作　　者：姜官鑫[1] 沈国清[1] 朱鸿林[1] 唐雯佳[1] 赏国锋[1] 王亭亭[1] 

机构地区：[1]上海交通大学农业与生物学院,农业部都市农业(南方)开放重点实验室,上海200240

出　　处：《科技通报》2012年第5期125-129,共5页Bulletin of Science and Technology

基　　金：国家自然科学基金(20877054);公益性行业(农业)科研专项(200903056);上海市科委科技攻关项目(08dz1900404);上海市科技兴农推广项目(沪农科推字2010第4-5号)

摘　　要：以聚乙二醇6000为载体，用熔融法制备了阿维菌素缓释固体分散体，并对其缓释性能和防紫外光降解作用进行了研究。结果表明，所制备的缓释固体分散体中，聚乙二醇6000对阿维菌素具有良好的包埋作用，包埋率可达94．23％～99．52％；阿维菌素的释放量随着温度的上升而上升，并具有良好的防紫外光降解的作用，其累积释放动力学方程为ARP=-91．6716e^-0．1022t＋98．1953，符合一级动力学释放模型。Controlled release solid dispersion of avermectin was prepared with Polyethylene glycol （PEG6000）as carriers by melting method. The release profiles and UV-shielding properties of the controlled release solid dispersion of aver- mectin were studied. The results indicated that avermectin was encapsulated by carriers PEG6000. The encapsulation ef- ficiencies were 94.23%-99.52%.The release contents of controlled solid dispersion was increased with the temperature rise. The accumulative release corresponded with first order kinetics model. The kinetics equation was ARP=-91.6716 e^-0.1022t ＋98.1953. The UV-shielding properties of the controlled solid dispersion were also favorable.

关 键 词：阿维菌素 固体分散体 缓释性能 聚乙二醇6000 

分 类 号：TQ450.68[化学工程—农药化工]