能量代谢因子促生长激素释放肽与青春期启动  

Energy metabolism factor ghrelin and puberty onset

作　　者：孙艳艳(综述)[1] 俞建(审校)[1] 田占庄(审校)[2] 

机构地区：[1]复旦大学附属儿科医院中医科,上海201102 [2]复旦大学上海医学院中西医结合系,上海200032

出　　处：《国际儿科学杂志》2012年第3期223-226,共4页International Journal of Pediatrics

基　　金：国家自然科学基金资助项目（81072841）

摘　　要：促生长激素释放肽与机体摄食和能量代谢的调节有关，同时能够调节机体与性激素分泌相关的促性腺激素类物质释放，是连接能量代谢与下丘脑一垂体一性腺轴的桥梁因子。生殖系统功能的启动与成熟与机体的营养状态密切相关，儿童青春期的启动需要一定的体脂储备，肥胖儿童青春期易提前启动，促生长激素释放肽可能是传递机体营养状态的信号因子之一，可能在青春期的启动中发挥一定的作用。Ghrelin is involved in the process of feeding behavior and regulation of related energy metabolism, it also modulates the secretion of gonadotropins or transmitters concerning sex hormone releasing. It is considered as the factor connecting the HPG axis and energy metabolism. Body＇s nutrition has a bearing upon the process of reproductive system＇s onset and maturation. Adequate body weight is necessary for normal puberty onset. Obese children tend to have an earlier menarche. Ghrelin may pass on the information about nutrition to the hypothamalus in puberty onset.

关 键 词：促生长激素释放肽 能量代谢 青春期 

分 类 号：R977.1[医药卫生—药品]