异构前列腺素与冠状动脉病变研究进展  

Progress of isoprostanes in the pathological changes of coronary artery

作　　者：张金旭(综述)[1] 朴金花(审校)[1] 金莲花(审校)[1] 

机构地区：[1]吉林大学第一医院儿科,长春130021

出　　处：《国际儿科学杂志》2012年第3期241-243,共3页International Journal of Pediatrics

摘　　要：异构前列腺素是氧自由基催化的脂质过氧化产物，其产生不依赖于环氧化酶和脂氧化酶。有研究表明氧化应激是冠状动脉病变发生的原因之一。8-异构前列腺素是异构前列腺素中含量最多的，也是研究最多的，属于不饱和二十烷脂肪酸，存在于磷脂的SN-2位置上。8-异构前列腺素作为反映脂质过氧化程度的特异、敏感、可靠的新指标，在冠状动脉病变中起重要作用。Isoprostanes are endogenously formed products of lipid peroxidation, furthermore, they are undependent on ring oxidase and lipoxygenase. Isoprostanes are established markers of oxidative stress. Furthermore, they are markers of oxidative stress and independent risk markers of coronary heart disease. Studies have indicated that oxidative stress is one of the reasons for the pathological changes of Coronary artery. 8-Iso-prosta- glandin F （2）, which is the maximum in isoprostanes, belongs to the unsaturated fatty acid （20）, exists in the phospholipid SN-2 position. 8-Iso-prostaglandin F （2）, a representative isoprostmae, is a specific, sensitive, reliable biomarker for enhanced oxidant stress in vivo, which plays an important role in coronary lesions.

关 键 词：异构前列腺素 氧化应激 冠状动脉病变 

分 类 号：R541.4[医药卫生—心血管疾病]