用于电穿孔效应实验的亚微秒脉冲电源研制  

Development of sub-microsecond pulser applied for electroporation effect

作　　者：吴建星[1] 杨宏春[1] 杨啸林[1] 张怡[2] 曾刚[1] 张晓宇[1] 

机构地区：[1]电子科技大学物理电子学院,四川成都610054 [2]四川大学华西妇女儿童医院,四川成都610041

出　　处：《实验技术与管理》2012年第5期94-97,共4页Experimental Technology and Management

基　　金：国家自然科学基金资助项目(10804016)

摘　　要：针对肿瘤细胞电穿孔效应的实验需求,用幅值可调的高压直流电源为电容充电,具有一定时间延时的2路TTL信号分别控制串联的2个IGBT模块的通与断,以便从电容放电曲线中截取适当脉宽电脉冲的方法,研制了一台输出脉冲电压0.5～3.5kV连续可调、脉宽300～800ns准连续可调、重频1～400Hz连续可调的亚微秒脉冲电源。实验测试结果表明,该脉冲电源性能稳定可靠,可用于恶性肿瘤电穿孔实验。A sub-microsecond pulse generator applied for electroporation effects of tumor cell is offered. The principle of the generator is intercepting an expectant pulse waveform from the RC discharge curve by controlling the on-off states of two IGBT modules through a synchronous controller. Experimental tests indicate that the generator can produce adjustable pulse waveform parameters with 0. 5--3. 5 kV amplitude, 300--800 ns pulse duration, 1--400 Hz repetition frequency, and it is suitable for the study of the experiments of electropo ration effects.

关 键 词：脉冲电源 IGBT模块 电穿孔效应 

分 类 号：Q233[生物学—细胞生物学] TN789.1[电子电信—电路与系统]